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. 2023 Feb 1;13(2):e064169. doi: 10.1136/bmjopen-2022-064169

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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Preferred Reporting Items for Systematic Reviews and Meta-Analyses diagram for clinical systematic review. MND, motor neuron disease; MS-SMART, Multiple Sclerosis-Secondary Progressive Multi-Arm Randomisation Trial; Ti/Ab, title/abstract.