Table 3.

Summary of preclinical studies evaluating the effect of interventions longlisted from the clinical review on survival outcomes

Publication	Drug	Total number of animals	Median survival in treatment group	Median survival in control group	LogMSR
Kira 2006	Acetyl-L-carnitine	20	270	240	0.1178
Barneoud 1999	Aspirin	38	150	155	−0.0328
Tanaka 2011	Bromocriptine	69	40	35	0.1335
Drachman 2002	Celecoxib	55	139	119	0.1554
Karlsson 2004	Ciclosporin	13	144	130	0.1023
Keep 2001	Ciclosporin	11	24	12	0.6931
Turner 2003	Clozapine	16	140	132	0.0588
Andreassen 2001	Creatine	24	155	135	0.1382
Kaddurah-Daouk 2000	Creatine	13	169	144	0.1601
Klivenyi 2004	Creatine	22	150	125	0.1823
Choi 2008	Oestrogen	70	135	127	0.0611
Koschnitzky 2014	Fluoxetine	34	139	132	0.0517
Gurney 1996	Gabapentin	17	140	139	0.0072
Gurney 1996	Gabapentin	38	175	165	0.0588
Ferrante 2001	Ginkgo biloba	20	136	125	0.0843
Fornai 2008	Lithium	20	146	117	0.2214
Gill 2009	Lithium	55	124	127	−0.0239
Pizzasegola 2009	Lithium	20	119	129	−0.0807
Dardiotis 2013	Melatonin	28	143	143	0.0000
Weishaupt 2006	Melatonin	50	137	131	0.0448
Zhang 2013	Melatonin	30	145	137	0.0568
Wang 2005	Memantine	21	130	122	0.0635
Keller 2011	Minocycline	32	147	138	0.0632
Kriz 2002	Minocycline	29	364	336	0.0800
Van Den Bosch 2002	Minocycline	14	155	130	0.1759
Zhang 2003	Minocycline	20	140	130	0.0741
Zhu 2002	Minocycline	20	135	127	0.0611
Andreassen 2000	N-acetyl cysteine	30	134	129	0.0380
Jaarsma 1998	N-acetyl cysteine	28	251	239	0.0490
Yip 2013	Omega 3	32	182	182	0.0000
Petri 2006	Sodium phenylbutyrate	26	139	127	0.0903
Ryu 2005	Sodium phenylbutyrate	40	145	127	0.1325
Crochemore 2009	Valproate	11	140	140	0.0000
Rouaux 2007	Valproate	36	115	110	0.0445
Sugai 2004	Valproate	17	295	265	0.1072
Gianfocaro 2013	Vitamin D	100	126	124	0.0160

All listed studies used mouse models. LogMSR=log(median survival in treatment group/median survival in control group).