Table 2.

Discovery analysis—Identification of CSF proteins differentially abundant POMS (n = 28) and pediatric mADS (n = 39).

Direction of difference in POMS	#	Accession	Gene	Protein description	Fold changea	# of peptidesb
Increased abundance	1	P01599	IGKV1-17	Immunoglobulin kappa variable 1-17	5.168	7
	2	P06331	IGHV4-34	Immunoglobulin heavy variable 4-34	4.768	3
	3	P01611	IGKV1D-12	Immunoglobulin kappa variable 1D-12	4.362	4
	4	P06312	IGKV4-1	Immunoglobulin kappa variable 4-1	4.267	10
	5	P06310	IGKV2-30	Immunoglobulin kappa variable 2-30	4.14	4
	6	P01615	IGKV2D-28	Immunoglobulin kappa variable 2D-28	3.342	6
	7	P01593	IGKV1D-33	Immunoglobulin kappa variable 1D-33	3.284	14
	8	P01824	IGHV4-39	Immunoglobulin heavy variable 4-39	2.656	2
	9	P01594	IGKV1-33	Immunoglobulin kappa variable 1-33	2.368	4
	10	P01834	IGKC	Immunoglobulin kappa constant	2.092	12
	11	P01857	IGHG1	Immunoglobulin heavy constant gamma 1	2.06	25
	12	P01859	IGHG2	Immunoglobulin heavy constant gamma 2	1.834	25
	13	P01763	IGHV3-48	Immunoglobulin heavy variable 3-48	1.76	4
	14	O75326	SEMA7A	Semaphorin-7A	1.736	8
	15	P04430	IGKV1-16	Immunoglobulin kappa variable 1-16	1.637	4
	16	Q96KN2	CNDP1	Beta-Ala-His dipeptidase	1.553	25
	17	P20933	AGA	N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	1.516	3
	18	P34096	RNASE4	Ribonuclease 4	1.509	2
	19	P16870	CPE	Carboxypeptidase E	1.463	13
	20	Q7Z7M0	MEGF8	Multiple epidermal growth factor-like domains protein 8	1.438	13
	21	Q06828	FMOD	Fibromodulin	1.39	3
	22	Q92876	KLK6	Kallikrein-6	1.386	11
	23	P26992	CNTFR	Ciliary neurotrophic factor receptor subunit alpha	1.341	3
	24	Q96 GW7	BCAN	Brevican core protein	1.329	14
	25	Q7Z3B1	NEGR1	Neuronal growth regulator 1	1.318	8
	26	Q02818	NUCB1	Nucleobindin-1	1.282	9
	27	Q9UBP4	DKK3	Dickkopf-related protein 3	1.232	18
	28	P80748	IGLV3-21	Immunoglobulin lambda variable 3-21	1.17	4
Decreased abundance	29	P18669	PGAM1	Phosphoglycerate mutase 1	0.847	5
	30	P01023	A2M	Alpha-2-macroglobulin	0.823	109
	31	O43866	CD5 L	CD5 antigen-like	0.798	8
	32	P01024	C3	Complement C3	0.748	147
	33	P04217	A1BG	Alpha-1B-glycoprotein	0.712	22
	34	Q96IY4	CPB2	Carboxypeptidase B2	0.684	3
	35	P00450	CP	Ceruloplasmin	0.682	65
	36	P10643	C7	Complement component C7	0.644	27
	37	Q06033	ITIH3	Inter-alpha-trypsin inhibitor heavy chain H3	0.617	9
	38	P23083	IGHV1-2	Immunoglobulin heavy variable 1-2	0.598	2
	39	P02788	LTF	Lactotransferrin	0.596	4
	40	P62937	PPIA	Peptidyl-prolyl cis-trans isomerase A	0.568	8
	41	Q86VB7	CD163	Scavenger receptor cysteine-rich type 1 protein M130	0.559	16
	42	Q9Y6R7	FCGBP	IgGFc-binding protein	0.533	55
	43	P80723	BASP1	Brain acid soluble protein 1	0.522	10
	44	P02763	ORM1	Alpha-1-acid glycoprotein 1	0.517	15
	45	P00739	HPR	Haptoglobin-related protein	0.482	20
	46	P59665	DEFA1	Neutrophil defensin 1	0.445	2
	47	O75015	FCGR3B	Low-affinity immunoglobulin gamma Fc region receptor III-B	0.425	2
Decreased abundance	48	P00738	HP	Haptoglobin	0.42	34
	49	P62328	TMSB4X	Thymosin beta-4	0.395	6
	50	P29966	MARCKS	Myristoylated alanine-rich C-kinase substrate	0.387	2
	51	P31946	YWHAB	14-3-3 protein beta/alpha	0.371	2
	52	P61626	LYZ	Lysozyme C	0.346	4
	53	Q08ET2	SIGLEC14	Sialic acid-binding Ig-like lectin 14	0.346	4
	54	P10153	RNASE2	Non-secretory ribonuclease	0.328	2
	55	P08637	FCGR3A	Low-affinity immunoglobulin gamma Fc region receptor III-A	0.305	2
	56	Q8TEU8	WFIKKN2	WAP, Kazal, immunoglobulin, Kunitz, and NTR domain-containing protein 2	0.289	8
	57	Q9Y279	VSIG4	V-set and immunoglobulin domain-containing protein 4	0.195	4
	58	P48539	PCP4	Calmodulin regulator protein PCP4	0.121	2

Proteins listed in table were identified differentially abundant between POMS and mADS with at least two unique peptides significantly different in discovery analysis. In bold, the proteins with increased abundance in POMS with at least eight unique peptides were significantly different.

^aFold change > 1 = increased abundance in POMS. Fold change < 1 = decreased abundance in POMS.

^bNumber of differentially identified peptides for the same protein.