In the CRC group (n = 301), CH and CH-PD were present in 83 (27.6%) and 44 (14.6%) patients, respectively. In the EGC group (n = 332), CH and CH-PD were present in 115 (34.6%) and 55 (16.6%) patients, respectively. The most frequently altered CH (A) and CH-PD (B) genes in the metastatic EGC and CRC groups (frequency, ≥0.01) and age at diagnosis for EGC and CRC groups based on CH (C) and CH-PD (D) status are shown.