Table 3. Univariable Analysis of CH-PD and OS Among Patients With Metastatic CRC .
| Characteristic | Univariable OS analysis | ||
|---|---|---|---|
| No. of patients | HR (95% CI) | P value | |
| CH-PD | |||
| Absent | 300 | 1 [Reference] | NA |
| Present | 1.18 (0.81-1.72) | .39 | |
| Diagnosis age | 300 | 1.01 (1.00-1.02) | .11 |
| Smoking history | |||
| Never smoker | 300 | 1 [Reference] | NA |
| Current/former | 1.04 (0.78-1.38) | .78 | |
| Prior RT or chemotherapy | |||
| None | 300 | 1 [Reference] | NA |
| Prior | |||
| RT and chemotherapy | 0.38 (0.23-0.63) | <.001 | |
| Prior chemotherapy only | 0.53 (0.39-0.72) | <.001 | |
| RT only | 2.69 (0.37-19.7) | .33 | |
| MMR status | |||
| MSS | 290 | 1 [Reference] | NA |
| MSI-H | 0.66 (0.42-1.05) | .08 | |
| TAB | 300 | 0.995 (0.988-1.001) | .11 |
Abbreviations: CH-PD, clonal hematopoiesis alterations annotated as likely putative drivers; CRC, colorectal cancer; MMR, mismatch repair; MSI-H, microsatellite instability–high; MSS, microsatellite stable; NA, not applicable; OS, overall survival; RT, radiotherapy; TAB, tumor alteration burden.