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. 2023 Feb 1;11(2):e005545. doi: 10.1136/jitc-2022-005545

Figure 4.

Figure 4

The rCXCL13 and anti-PD-1 lead to recruitment of antigen-experienced T cells. Uniform Manifold Approximation and Projection (UMAP) of total CD45+ cells from combining all treatment groups in (A) HKP1, (B) MC38 or (C) LLC1 models. (D) Average frequency of CCR2− monocytes in IgG+ PBS control tumors. Average frequency of CCR2− monocytes in (E) HKP1, (F) MC38, (G) LLC1. UMAP plot of all T cells highlighting antigen-experienced CD4+ and CD8+ T-cell abundance in (H) HKP1, (J) MC38 or (L) LLC1 models with indicated treatments. Average frequency of dendritic cells in (I) HKP1 or CD8+ T cells in (K) MC38 and (J) LLC1 models. Mean±SEM. Statistical analysis (D–M: one-way analysis of variance with Tukey multiple comparisons test). PBS, phosphate-buffered saline; PD-1, programmed cell death protein-1; rCXCL13, recombinant CXCL13; Tregs, regulatory T cells.