Table 1. Cost for Resource Utilization During the Trial and Mapping From Visual Acuity to Utility.
| Parameter | Base value (range) | Distributiona | Notes |
|---|---|---|---|
| Costs, $ | |||
| OCT (for all visits) | 41.18 (30.89-51.48) | Normal | CPT code 92134 |
| Injection procedure (for visits with injection) | 114.20 (85.65-142.75) | Normal | CPT code 67028 |
| Aflibercept, 2 mg | 1831.49 (1373.62-2289.37) | Normal | CPT code J0178 |
| Bevacizumab | 67.86 (50.9-84.83) | Normal | CPT code J9035 |
| Annual discount rate, % | 3 (0-7) | Normal | NA |
| Utilities | |||
| Visual acuity letter score in better-seeing eye | |||
| 100 (20/10) | 0.97 (0.95-1.00) | Correlated normal | Brown et al,82003 |
| 83-99 (20/25-20/10) | 0.92 (0.87-0.97) | Correlated normal | NA |
| 79-82 (20/25) | 0.87 (0.82-0.92) | Correlated normal | NA |
| 74-78 (20/32) | 0.84 (0.79-0.89) | Correlated normal | NA |
| 68-73 (20/50-20/40) | 0.80 (0.74-0.86) | Correlated normal | NA |
| 62-67 (20/63-20/50) | 0.77 (0.7-0.84) | Correlated normal | NA |
| 55-61 (20/80-20/63) | 0.74 (0.67-0.81) | Correlated normal | NA |
| 43-54 (20/160-20/80) | 0.67 (0.57-0.77) | Correlated normal | NA |
| 31-42 (20/250-20/160) | 0.66 (0.55-0.77) | Correlated normal | NA |
| 24-30 (20/320-20/250) | 0.63 (0.54-0.72) | Correlated normal | NA |
| 19-23 (20/400) | 0.54 (0.43-0.65) | Correlated normal | NA |
| 1-18 (<20/800-20/500) | 0.52 (0.36-0.68) | Correlated normal | NA |
| 0 | 0.35 (0.1-0.60) | Correlated normal | NA |
| Visual acuity letter score in treated eye (sensitivity analysis) | NA | ||
| 86-100 (20/20-20/10) | 0.86 (0.793-0.927) | Correlated normal | RESTORE; Mitchell et al,9 2012 |
| 76-85 (20/32-20/20) | 0.86 (0.833-0.887) | Correlated normal | NA |
| 66-75 (20/50-20/32) | 0.813 (0.789-0.837) | Correlated normal | NA |
| 56-65 (20/80-20/50) | 0.802 (0.775-0.829) | Correlated normal | NA |
| 46-55 (20/125-20/80) | 0.770 (0.735-0.805) | Correlated normal | NA |
| 36-45 (20/200-20/125) | 0.760 (0.707-0.813) | Correlated normal | NA |
| 26-35 (20/320-20/200) | 0.681 (0.577-0.785) | Correlated normal | NA |
| 0-25 (<20/800-20/320) | 0.547 (0.384-0.71) | Correlated normal | NA |
Abbreviations: CPT, Current Procedural Terminology; NA, not applicable; OCT, optical coherence tomography.
a
Correlated normal indicates that the utilities drawn for the Monte Carlo simulation have a correlation of 0.75 between adjacent visual acuity levels.