|
Clinical baseline parameters
|
|
Age, years
|
82.2 (78.4, 85.4)
|
81.9 (78.1, 85.3)
|
0.29
|
|
Sex, male
|
158 (44.1)
|
162 (45.3)
|
0.82
|
|
BMI, kg/m2
|
25.5 (23.2, 29.0)
|
25.7 (23.3, 29.3)
|
0.41
|
|
STS PROM, %
|
4.5±2.7
|
5.0±3.4
|
0.08
|
|
EuroSCORE II
|
5.4±5.1
|
5.5±6.3
|
0.85
|
|
Diabetes (insulin dependent)
|
30 (8.4)
|
41 (11.5)
|
0.21
|
|
Atrial fibrillation
|
92 (25.7)
|
105 (29.3)
|
0.32
|
|
Peripheral artery disease
|
74 (20.7)
|
77 (21.5)
|
0.85
|
|
Prior pacemaker/ICD
|
39 (10.9)
|
37 (10.3)
|
0.90
|
|
eGFR (CKD-EPI), mL/min/1.73 m2
|
58.7 (43.5, 72.9)
|
57.5 (41.5, 74.2)
|
0.70
|
|
sPAP >55 mHg
|
55 (15.4)
|
47 (13.1)
|
0.45
|
|
NYHA III
|
271 (75.7)
|
259 (72.3)
|
0.35
|
|
NYHA IV
|
38 (10.6)
|
45 (12.6)
|
0.48
|
|
Echocardiographic baseline parameters
|
|
p mean, mmHg
|
33.0 (24.0, 47.0)
|
36.0 (25.0, 47.0)
|
0.28
|
|
EOA, cm2
|
0.8 (0.6, 0.9)
|
0.7 (0.6, 0.9)
|
0.002
|
|
SVI, mL/m2
|
38.2 (28.7, 46.3)
|
36.6 (28.9, 44.2)
|
0.26
|
|
Mitral regurgitation ≥II°
|
110 (30.9)
|
116 (32.7)
|
0.67
|
|
LVEF <30%
|
48 (13.4)
|
34 (9.5)
|
0.13
|
|
MSCT baseline parameters
|
|
CT threshold, HU
|
560.5±64.1
|
548.6±67.5
|
0.02
|
|
Annulus perimeter derived diameter, mm
|
24.6 (22.9, 26.3)
|
24.4 (22.7, 26.3)
|
0.61
|
|
Annulus area, cm2
|
461.5 (399.4, 525.1)
|
460.6 (391.2, 529.6)
|
0.98
|
|
LVOT perimeter derived diameter, mm
|
25.1 (23.2, 26.9)
|
25.1 (23.3, 27.3)
|
0.98
|
|
LVOT area, cm2
|
461.8 (383.7, 528.6)
|
455.9 (392.5, 540.4)
|
0.74
|
|
Total AVC calcium volume, mm3
|
455.0 (262.2, 776.6)
|
726.6 (423.0, 1148.0)
|
<0.001
|
|
Calcium volume annular plane, mm3
|
455.0 (261.4, 775.0)
|
654.2 (364.5, 1043.7)
|
<0.001
|
|
Calcium volume LVOT, mm3
|
0 (0, 0.6)
|
49.9 (22.4, 106.9)
|
<0.001
|
|
AVC density, mm3 calcium/cm2
|
102.4 (58.4, 162.3)
|
157.1 (96.1, 239.7)
|
<0.001
|
|
*Without ≤10 mm3 LVOT calcium volume. **With >10 mm3 LVOT calcium volume. Values are mean±SD, n (%) unless otherwise indicated or median (interquartile range). AVC: aortic valve complex; COPD: chronic obstructive pulmonary disease; eGFR: estimated glomerular filtration rate; EOA: effective orifice area; EuroSCORE: European System for Cardiac Operative Risk Evaluation; HU: Hounsfield units; ICD: implantable cardioverter defibrillator; LVEF: left ventricular ejection fraction; LVOT: left ventricular outflow tract; MSCT: multislice computed tomography; NYHA: New York Heart Association; sPAP: systolic pulmonary artery pressure; STS PROM: Society of Thoracic Surgeons Predicted Risk of Mortality; SVI: stroke volume index
|
