Table 2. List of Obtained Posaconazole Cocrystals and Their Solid-State Properties.
| cocrystal | coformer | stoichiometry | coformer Tmelting (°C) | cocrystal Tmelting (°C) | TG–FTIR |
|---|---|---|---|---|---|
| PSZ–MLE | maleic acid | 1:1 | 130–135 | 146 | anhydrous |
| PSZ–MLA | l-malic acid | 2:1 | 101–103 | 131 | anhydrous |
| PSZ–CIT | citric acid | 4:1 | 153–159 | 156 | anhydrous |
| PSZ–XIN | 1-hydroxy-2-naphthoic acid | 1:1 | 195–200 | 157 | anhydrous |
| PSZ–GEN | gentisic acid | 1:1 | 182–184 | 150 | anhydrous |
| PSZ–SAL | salicylic acid | 1:1 | 158–161 | 125 | anhydrous |
| PSZ–ABA | 4-aminobenzoic acid | 2:3 | 187–189 | 153 | anhydrous |
| PSZ–LLA | l-lactic acid | 1:1 | 53–54 | 126 | anhydrous |
| PSZ–ADI–H2O | adipic acid | 2:1:1 | 151–154 | 1.3% H2O | |
| PSZ–FER–H2O | trans-ferulic acid | 3:1:1 | 168–172 | 0.9% H2O | |
| PSZ–SUC–H2O | succinic acid | 2:1:1 | 184–186 | 1% H2O | |
| PSZ–FUM–THF | fumaric acid | 1:1:1 | 298–300 | 10% THF | |
| PSZ–FUM–H2O | fumaric acid | 1:1:0.5 | 298–300 | 1% H2O | |
| PSZ–DHB–H2O | 3,4-dihydroxybenzoic acid | 3:4:2 | 197–200 | 1.4% H2O |