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. 2023 Jan 5;34(2):264–272. doi: 10.1021/jasms.2c00281

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© 2023 The Authors. Published by American Chemical Society

Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).

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DESI-MSI analysis of murine brain. (a) A representative DESI mass spectrum (i) obtained as part of an MSI experiment on the murine brain. The lipid envelope is observed between 700 and 900 m/z. The murine brain section, shown as an H and E stained optical image (ii) was imaged in its entirety. A selection of identified species is shown in an overlaid molecular image (iii). Signals correspond to putative identifications of PC (38:5) (808.58542 m/z, blue, 420 ppb), PC (36:1) (788.61609 m/z, red, −370 ppb), PC (38:6) (806.56909 m/z, green, −423 ppb), PC (40:6) (834.60034 m/z, coral, 469 ppb), and Heme (616.17682 m/z, violet, 101 ppb). (b) Demonstration of the power of the high resolution MRT for imaging. A lipid signal corresponding to PC (33:1) is well-resolved from nearby lipid species but also from interfering background. On a lower resolution system, the background would interfere with the PC (33:1) signal yielding a composite image.