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Mechanism of action of octicidine (PSorn), the toxic moiety of phaseolotoxin. PSorn is an irreversible inhibitor of OCTase, a critical enzyme in the urea cycle which converts ornithine and carbamoyl phosphate to citrulline. Inhibition of OCTase causes an accumulation of ornithine and a deficiency in intracellular pools of arginine, leading to chlorosis. Diagonal parallel lines indicate the block in the urea cycle elicited by PSorn.
