. 2023 Jan 28;29(4):616–655. doi: 10.3748/wjg.v29.i4.616

Table 1.

Exogenous modulators of ferroptosis

Inducers	Mechanisms	Compounds
Class 1	Inhibition of system Xc-	Erastin, sorafenib, sulfasalazin
Class 1	Prevention of cystine import	Glutamate
Class 2	Inhibition of GPX4	RLS3, DPIs (DPI7, DPI10)
Class 3	Degradation of GPX4	FIN56
Class 3	Depletion of CoQ10	FIN56
Class 4	Initiation of lipid peroxidation	FINO2, PUFAs
Class 4	Indirect reduction of GPX4 activity	FINO2, PUFAs
Inhibitors
Class 1	Suppression of iron accumulation	Deferoxamine
Class 2	Inhibition of lipid peroxidation	Ferrostatin-1, liproxstatin-1, vitamin E
Unclassified		Dynasore, probucol, selenium, nitroxide XJB-5-131
Unclassified		Bicyclol, rosiglitazone

CoQ10: Coenzyme Q10; FIN: Ferroptosis inducing compounds; GPX4: Glutathione peroxidase 4; PUFAs: Polyunsaturated fatty acids.