Inhibition percentages of NCI hits against 5 different cell lines at 10 μM as determined by MTT assay. Each measurement represents average of 4 trials.
| Compound | HEK-293 | MCF-7 | U87 | MDA-MB-231 | Fibroblasts |
|---|---|---|---|---|---|
| 317 | 0 | 7 | 3 | 0 | 0 |
| 318 | 8 | 14 | 4 | 0 | 0 |
| 319 | 60 | 46 | 21 | 36 | 7 |
| 320 | 26 | 8 | 23 | 10 | 0 |
| 321 | 27 | 9 | 3 | 0 | 4 |
| 322 | 11 | 22 | 7 | 23 | 9 |
| 323 | 2 | 13 | 13 | 2 | 0 |
| 324 | 0 | 13 | 7 | 6 | 0 |
| 325 | 38 | 13 | 38 | 8 | 30 |
| 326 | 0 | 3 | 1 | 15 | 10 |
| 327 | 3 | 3 | 0 | 0 | 11 |
| 328 | 0 | 16 | 0 | 0 | 11 |
| 329 | 10 | 15 | 0 | 0 | 12 |
| 330 | 6 | 17 | 0 | 0 | 14 |
| 331 | 0 | 24 | 0 | 2 | 25 |
| 332 | 14 | 20 | 10 | 3 | 0 |
| 333 | 53 | 24 | 3 | 24 | 1 |
| 334 | 39 | 37 | 0 | 1 | 14 |
| 335 | 3 | 21 | 9 | 9 | 18 |
| 336 | 11 | 25 | 0 | 0 | 2 |
| 337 | 37 | 0 | 0 | 21 | 11 |
| 338 | 0 | 12 | 0 | 0 | 13 |
| 339 | 0 | 0 | 16 | 0 | 7 |
| 340 | 31 | 3 | 5 | 0 | 2 |
| 341 | 42 | 44 | 32 | 21 | 7 |
| 342 | 53 | 39 | 18 | 20 | 23 |
| Pyrimethaminea | 53 | 31 | 19 | 20 | 7 |
| Stattica | 88 | 92 | 90 | 87 | 81 |
a
Standard STAT3 inhibitors.