Table 1.
Demographics of Participants Listed for Transplantation
| Before the 2015 LAS Revision |
After the 2015 LAS Revision |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Overall | Group B (PAH) | Group A (COPD) | Group C (CF) | Group D (ILD) | Overall | Group B (PAH) | Group A (COPD) | Group C (CF) | Group D (ILD) | |
| No. (%) | 20,197 (100) | 997 (5) | 5,796 (29) | 2,572 (13) | 10,832 (54) | 19,478 (100) | 1,212 (6) | 4,522 (23) | 1,545 (8) | 12,199 (63) |
| Age, yr | 52.3 ± 15.6 | 38.8 ± 19.4 | 57.9 ± 9.0 | 28.6 ± 10.9 | 56.2 ± 12.9 | 56.3 ± 14.2 | 46.6 ± 17.6 | 60.2 ± 8.6 | 31.1 ± 11.8 | 59.0 ± 11.9 |
| Female | 8,885 (44) | 647 (65) | 2,951 (51) | 1,322 (51) | 3,965 (37) | 8,297 (43) | 802 (66) | 2,281 (50) | 818 (53) | 4,396 (36) |
| Race | ||||||||||
| White | 16,566 (82) | 703 (71) | 5,131 (89) | 2,381 (93) | 8,351 (77) | 14,670 (75) | 754 (62) | 3,845 (85) | 1,342 (87) | 8,729 (72) |
| Black | 1,802 (9) | 137 (14) | 479 (8) | 42 (2) | 1,144 (11) | 1,985 (10) | 193 (16) | 471 (11) | 52 (3) | 1,269 (10) |
| Other | 1,829 (9) | 157 (16) | 196 (3) | 149 (6) | 1,337 (12) | 2,823 (14) | 265 (22) | 206 (5) | 151 (10) | 2,201 (18) |
| Organ desired | ||||||||||
| Bilateral | 10,980 (54) | 896 (89) | 2,940 (51) | 2,467 (96) | 4,677 (43) | 11,642 (60) | 1,035 (85) | 2,714 (60) | 1,466 (95) | 6,427 (53) |
| Unilateral | 9,217 (46) | 101 (10) | 2,856 (49) | 105 (4) | 6,155 (57) | 7,836 (40) | 177 (15) | 1,808 (40) | 79 (5) | 5,772 (47) |
| Initial LAS | 40.7 ± 17.5 | 34.4 ± 9.5 | 32.3 ± 9.3 | 38.8 ± 16.2 | 46.3 ± 19.5 | 43.9 ± 16.8 | 44.5 ± 12.7 | 34.2 ± 7.8 | 44.2 ± 17.6 | 47.4 ± 18.0 |
| End LAS | 47.5 ± 21.6 | 34.2 ± 14.8 | 34.3 ± 12.9 | 48.5 ± 21.2 | 55.6 ± 21.8 | 49.7 ± 20.3 | 48.4 ± 16.3 | 35.6 ± 10.7 | 51.3 ± 21.8 | 54.7 ± 20.7 |
| Delta LAS | 6.8 ± 18.2 | 0.32 ± 13.2 | 2.0 ± 13.4 | 9.7 ± 20.1 | 9.4 ± 19.6 | 5.7 ± 14.5 | 3.9 ± 12.4 | 1.4 ± 10.0 | 7.1 ± 18.2 | 7.3 ± 15.3 |
| Delta LAS/day | 0.4 ± 2.8 | 0.1 ± 0.9 | 0.1 ± 1.6 | 0.4 ± 2.9 | 0.5 ± 3.4 | 0.3 ± 1.6 | 0.2 ± 1.3 | 0.1 ± 1.7 | 0.4 ± 2.8 | 0.3 ± 1.7 |
| Days observed | 195 ± 317 | 270 ± 395 | 297 ± 403 | 204 ± 299 | 132 ± 234 | 136 ± 224 | 175 ± 282 | 207 ± 285 | 156 ± 237 | 103 ± 178 |
| Days to death | 221 ± 340 | 262 ± 357 | 473 ± 493 | 219 ± 311 | 140 ± 237 | 143 ± 214 | 138 ± 212 | 297 ± 309 | 138 ± 166 | 116 ± 184 |
| Days to transplant | 153 ± 249 | 168 ± 220 | 222 ± 322 | 181 ± 266 | 109 ± 183 | 105 ± 174 | 119 ± 209 | 160 ± 226 | 116 ± 175 | 83 ± 141 |
| ECMO at listing | 279 (1) | 19 (2) | 38 (1) | 7 (0.1) | 215 (2) | 583 (5) | 75 (6) | 19 (0.4) | 81 (5) | 583 (5) |
| Die waiting | 1,923 (10) | 192 (19) | 331 (6) | 264 (10) | 1,136 (10) | 1,012 (5) | 93 (8) | 131 (3) | 69 (5) | 719 (6) |
| Die/delist | 3,180 (16) | 260 (26) | 630 (11) | 418 (16) | 1,872 (17) | 1,896 (10) | 162 (13) | 265 (6) | 104 (7) | 1,365 (11) |
| Transplanted | 15,609 (77) | 538 (54) | 4,592 (79) | 2,001 (78) | 8,478 (78) | 15,566 (80) | 770 (64) | 3,652 (81) | 1,277 (83) | 9,857 (81) |
Definition of abbreviations: CF = cystic fibrosis; COPD = chronic obstructive pulmonary disease; ECMO = extracorporeal membrane oxygenation; ILD = interstitial lung disease; LAS = lung allocation score; PAH = pulmonary arterial hypertension.
Categorical data presented as n (%). Continuous data presented as mean ± SD. Registrants stratified by LAS category. LAS category A represents registrants with COPD. LAS category B represents registrants with PAH. LAS category C represents registrants with CF. LAS category D represents registrants with ILD.