Table 3.
Odds (and 95% confidence intervals) of experiencing the minimum clinically important difference in 6 min walk distance from baseline to week 24 associated with lung function and biomarker values at baseline, changes in values from baseline to week 4, and changes in values from baseline to week 12
| Changes from baseline to week 4 (N = 77), OR (95% CI) | Changes from baseline to week 12 (N = 78), OR (95% CI) | |
|---|---|---|
| Forced vital capacity (FVC, 100 ml)* | 1.03 (0.94, 1.13) | 1.11 (1.00, 1.25) |
| FVC predicted (%)* | 1.08 (0.92, 1.28) | 1.22 (1.01, 1.52) |
| Forced expiratory volume in 1 s (FEV1, 100 ml)* | 1.10 (0.99, 1.24) | 1.17 (1.05, 1.33) |
| FEV1 predicted (%)* | 1.13 (0.98, 1.34) | 1.20 (1.03, 1.43) |
| COPD** assessment test total score | 0.97 (0.91, 1.04) | 0.94 (0.87, 1.01) |
| Collagen Ia (1000 pg/L) | 1.32 (0.99, 1.83) | 1.31 (1.08, 1.62) |
| TIMP1 (100000 pg/L) | 1.00 (0.93, 1.07) | 0.97 (0.91, 1.03) |
| CCL2 (100 pg/L) | 1.32 (0.75, 2.40) | 1.41 (0.88, 2.35) |
| CXCL11 (10 pg/L) | 1.01 (0.95, 1.08) | 1.01 (0.95, 1.07) |
| IL8 (pg/L) | 1.02 (0.97, 1.07) | 1.02 (0.94, 1.11) |
| MMP-1 (100 pg/L) | 1.02 (0.96, 1.10) | 1.02 (0.96, 1.08) |
| VCAM1 (1000000 pg/L) | 0.75 (0.50, 1.06) | 0.69 (0.43, 1.06) |
| CXCL10 (100 pg/L) | 1.08 (1.00, 1.22) | 1.02 (0.95, 1.12) |
| IL6 (10 pg/L) | 1.12 (0.93, 1.68) | 1.13 (0.64, 2.15) |
| M-CSF (100 pg/L) | 1.03 (0.98, 1.08) | 0.99 (0.94, 1.03) |
| Plasminogen activator (100 pg/L) | 0.88 (0.72, 1.05) | 1.01 (0.86, 1.19) |
| VEGF (pg/L) | 1.01 (0.97, 1.06) | 1.02 (0.97, 1.07) |
*n = 79 at baseline, n = 68 at changes at week4, and n = 63 at changes at week12
**COPD, Chronic obstructive pulmonary disease