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. 2023 Feb 3;20:11. doi: 10.1186/s12987-023-00411-w

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Endogenous tPA levels influence NVC. A Schematic representation of the procedure of whisker stimulations paradigm between two mice (tPA^Null and tPA^WT) in parabiosis. tPA from the donor (tPA^WT) will be share to the recipient (tPA^Null). B Colormap corresponds to the activation map related ∆CBF changes during whisker stimulations in parabiont tPA^Null or tPA^WT mice. Warm colours indicate an elevation of CBF during whisker stimulations. C, D Time course of % CBF increase (mean ± SEM) during whisker stimulations () in homo-parabiosis tPA^WT () and tPA^Null () mice (C) and hetero-parabiosis tPA^WT () and tPA^Null () mice (D). E Box plots show the variation of % CBF increase from baseline during whisker stimulations in homo-parabiosis tPA^WT/tPA^WT and tPA^Null/tPA^Null, and hetero-parabiosis tPA^WT/tPA^Null and tPA^Null/tPA^WT (the stimulated mouse is mentioned in bold). Box plots with medians, 1st and 3rd quartiles, min and max with values for each mouse. *p < 0.05 and from tPA^Null/tPA^Null, one-way ANOVA and Uncorrected Fisher’s LSD tests, n = 7 tPA^WT/tPA^WT, n = 8 tPA^Null/tPA^Null, n = 9 tPA^WT/tPA^Null, n = 10 tPA^Null/tPA^WT (n represents the number of stimulated animals)

Inline graphic — Endogenous tPA levels influence NVC. A Schematic representation of the procedure of whisker stimulations paradigm between two mice (tPA^Null and tPA^WT) in parabiosis. tPA from the donor (tPA^WT) will be share to the recipient (tPA^Null). B Colormap corresponds to the activation map related ∆CBF changes during whisker stimulations in parabiont tPA^Null or tPA^WT mice. Warm colours indicate an elevation of CBF during whisker stimulations. C, D Time course of % CBF increase (mean ± SEM) during whisker stimulations () in homo-parabiosis tPA^WT () and tPA^Null () mice (C) and hetero-parabiosis tPA^WT () and tPA^Null () mice (D). E Box plots show the variation of % CBF increase from baseline during whisker stimulations in homo-parabiosis tPA^WT/tPA^WT and tPA^Null/tPA^Null, and hetero-parabiosis tPA^WT/tPA^Null and tPA^Null/tPA^WT (the stimulated mouse is mentioned in bold). Box plots with medians, 1st and 3rd quartiles, min and max with values for each mouse. *p < 0.05 and from tPA^Null/tPA^Null, one-way ANOVA and Uncorrected Fisher’s LSD tests, n = 7 tPA^WT/tPA^WT, n = 8 tPA^Null/tPA^Null, n = 9 tPA^WT/tPA^Null, n = 10 tPA^Null/tPA^WT (n represents the number of stimulated animals)