Table 1.
Demographic and clinical characteristics comparing small cell carcinoma of the ovary and high-grade serous ovarian cancer.
| Subject Characteristic | Before propensity score matching | P-value | After propensity score matching | SD | ||
|---|---|---|---|---|---|---|
| HGSOC | SCCO | HGSOC | SCCO | |||
| N(%) | N(%) | N(%) | N(%) | |||
| All | 31979 | 206 | 628 | 181 | ||
| Year of diagnosis | ||||||
| 2000-2001 | 3117 (9.7) | 21 (10.2) | 0.851 | 66 (10.5) | 18 (9.9) | 0.052 |
| 2002-2015 | 24880 (77.8) | 157 (76.2) | 486 (77.4) | 138 (76.2) | ||
| 2016-2017 | 3982 (12.5) | 28 (13.6) | 76 (12.1) | 25 (13.8) | ||
| Laterality | ||||||
| Bilateral | 16313 (51.0) | 27 (13.1) | <0.001 | 92 (14.6) | 27 (14.9) | 0.06 |
| Left | 6003 (18.8) | 73 (35.4) | 221 (35.2) | 61 (33.7) | ||
| Only one side - side unspecified | 290 (0.9) | 3 (1.5) | 8 (1.3) | 3 (1.7) | ||
| Paired site, but no information concerning laterality | 3038 (9.5) | 18 (8.7) | 69 (11.0) | 18 (9.9) | ||
| Right | 6335 (19.8) | 85 (41.3) | 238 (37.9) | 72 (39.8) | ||
| Surgery status | ||||||
| No surgery | 3492 (10.9) | 43 (20.9) | <0.001 | 136 (21.7) | 41 (22.7) | 0.024 |
| Surgery | 28447 (89.0) | 163 (79.1) | 492 (78.3) | 140 (77.3) | ||
| Unknown | 40 (0.1) | 0 (0.0) | 0 (0.0) | 0 (0.0) | ||
| Radiation therapy | ||||||
| No radiation | 31709 (99.2) | 192 (93.2) | <0.001 | 607 (96.7) | 177 (97.8) | 0.069 |
| Radiation | 270 (0.8) | 14 (6.8) | 21 (3.3) | 4 (2.2) | ||
| Chemotherapy status | ||||||
| Chemotherapy | 6676 (20.9) | 50 (24.3) | 0.267 | 168 (26.8) | 48 (26.5) | 0.005 |
| No chemotherapy/Unknown | 25303 (79.1) | 156 (75.7) | 460 (73.2) | 133 (73.5) | ||
| Number of primary tumors | ||||||
| 1st of 2 or more primaries | 2453 (7.7) | 12 (5.8) | 0.389 | 42 (6.7) | 12 (6.6) | 0.002 |
| One primary only | 29526 (92.3) | 194 (94.2) | 586 (93.3) | 169 (93.4) | ||
| Race | ||||||
| Black | 2182 (6.8) | 16 (7.8) | 0.225 | 38 (6.1) | 16 (8.8) | 0.116 |
| Other (American Indian/AK Native, Asian/Pacific Islander) | 2526 (7.9) | 18 (8.7) | 54 (8.6) | 17 (9.4) | ||
| Unknown | 85 (0.3) | 2 (1.0) | 5 (0.8) | 1 (0.6) | ||
| White | 27186 (85.0) | 170 (82.5) | 531 (84.6) | 147 (81.2) | ||
| Marital status at diagnosis | ||||||
| DSW | 8794 (27.5) | 30 (14.6) | <0.001 | 113 (18.0) | 28 (15.5) | 0.089 |
| Married | 16988 (53.1) | 79 (38.3) | 264 (42.0) | 74 (40.9) | ||
| Single | 4997 (15.6) | 90 (43.7) | 226 (36.0) | 72 (39.8) | ||
| Unknown | 1200 (3.8) | 7 (3.4) | 25 (4.0) | 7 (3.9) | ||
| Median household income ($) | ||||||
| <50,000 | 3542 (11.1) | 35 (17.0) | <0.001 | 106 (16.9) | 29 (16.0) | 0.036 |
| >=70,000 | 13766 (43.0) | 63 (30.6) | 207 (33.0) | 58 (32.0) | ||
| 50,000-69,999 | 14671 (45.9) | 108 (52.4) | 315 (50.2) | 94 (51.9) | ||
| Age (years) | ||||||
| <=51 | 6532 (20.4) | 141 (68.4) | <0.001 | 354 (56.4) | 116 (64.1) | 0.165 |
| >=74 | 6844 (21.4) | 23 (11.2) | 107 (17.0) | 23 (12.7) | ||
| 52-73 | 18603 (58.2) | 42 (20.4) | 167 (26.6) | 42 (23.2) | ||
| Grade | ||||||
| I/II | 4524 (14.1) | 1 (0.5) | <0.001 | 8 (1.3) | 1 (0.6) | 0.083 |
| III/IV | 20364 (63.7) | 107 (51.9) | 327 (52.1) | 92 (50.8) | ||
| Unknown | 7091 (22.2) | 98 (47.6) | 293 (46.7) | 88 (48.6) | ||
| Seer stage | ||||||
| Distant | 24812 (77.6) | 122 (59.2) | <0.001 | 406 (64.6) | 114 (63.0) | 0.051 |
| Localized | 1706 (5.3) | 26 (12.6) | 68 (10.8) | 19 (10.5) | ||
| Regional | 4933 (15.4) | 53 (25.7) | 140 (22.3) | 43 (23.8) | ||
| Unknown | 528 (1.7) | 5 (2.4) | 14 (2.2) | 5 (2.8) | ||
| Stage | ||||||
| I | 2771 (8.7) | 44 (21.4) | <0.001 | 105 (16.7) | 31 (17.1) | 0.086 |
| II | 2269 (7.1) | 15 (7.3) | 51 (8.1) | 14 (7.7) | ||
| III | 15489 (48.4) | 65 (31.6) | 224 (35.7) | 58 (32.0) | ||
| IV | 9140 (28.6) | 62 (30.1) | 188 (29.9) | 59 (32.6) | ||
| Unknown | 2310 (7.2) | 20 (9.7) | 60 (9.6) | 19 (10.5) | ||
| tumor size (mm) | ||||||
| <=92 | 11859 (37.1) | 38 (18.4) | <0.001 | 136 (21.7) | 37 (20.4) | 0.1 |
| >=141 | 3108 (9.7) | 79 (38.3) | 176 (28.0) | 59 (32.6) | ||
| 93-140 | 5081 (15.9) | 42 (20.4) | 141 (22.5) | 38 (21.0) | ||
| Unknown | 11931 (37.3) | 47 (22.8) | 175 (27.9) | 47 (26.0) | ||
| Lymph nodes status | ||||||
| negative | 7586 (23.7) | 59 (28.6) | 0.18 | 177 (28.2) | 46 (25.4) | 0.063 |
| positive | 7094 (22.2) | 38 (18.4) | 113 (18.0) | 34 (18.8) | ||
| Unknown | 17299 (54.1) | 109 (52.9) | 338 (53.8) | 101 (55.8) | ||
| CA125 | ||||||
| negative | 1283 (4.0) | 18 (8.7) | <0.001 | 41 (6.5) | 16 (8.8) | 0.095 |
| positive | 19475 (60.9) | 92 (44.7) | 291 (46.3) | 85 (47.0) | ||
| Unknown | 11221 (35.1) | 96 (46.6) | 296 (47.1) | 80 (44.2) | ||