Table 2.
Univariable Cox Regression for analyzing the associated factors for small cell carcinoma of the ovary.
| Subject characteristics | Overall survival (OS) | Cancer-specific survival (CSS) | ||
|---|---|---|---|---|
| HR (95%CI) | P-value | HR (95%CI) | P-value | |
| Year of diagnosis | ||||
| 2000-2001 | Reference | Reference | ||
| 2002-2015 | 1.28(0.77~2.13) | 0.347 | 1.96(0.99~3.89) | 0.053 |
| 2016-2017 | 1.33(0.69~2.56) | 0.389 | 2.19(0.98~4.88) | 0.057 |
| Laterality | ||||
| Bilateral | Reference | Reference | ||
| Left | 0.5(0.31~0.8) | 0.004 | 0.55(0.33~0.94) | 0.028 |
| Only one side - side unspecified | 8.96(2.53~31.65) | 0.001 | 12.27(3.34~45.08) | <0.001 |
| Paired site, but no information concerning laterality | 1.84(1~3.38) | 0.05 | 0.88(0.37~2.1) | 0.774 |
| Right | 0.43(0.27~0.68) | <0.001 | 0.52(0.31~0.88) | 0.015 |
| Surgery status | ||||
| No surgery | Reference | Reference | ||
| Surgery | 0.26(0.18~0.38) | <0.001 | 0.35(0.22~0.54) | <0.001 |
| Radiation therapy | ||||
| No radiation | Reference | Reference | ||
| Radiation | 0.35(0.15~0.79) | 0.012 | 0.36(0.15~0.89) | 0.027 |
| Chemotherapy status | ||||
| Chemotherapy | Reference | Reference | ||
| No chemotherapy/Unknown | 0.43(0.3~0.61) | <0.001 | 0.49(0.33~0.74) | 0.001 |
| Number of primary tumors | ||||
| 1st of 2 or more primaries | Reference | Reference | ||
| One primary only | 2(0.93~4.28) | 0.076 | 3.65(1.16~11.52) | 0.027 |
| Race | ||||
| Black | Reference | Reference | ||
| Other (American Indian/AK Native, Asian/Pacific Islander) | 0.76(0.35~1.64) | 0.487 | 0.89(0.37~2.14) | 0.799 |
| Unknown | NA | 0.994 | NA | NA |
| White | 0.92(0.53~1.6) | 0.772 | 1.05(0.55~2.02) | 0.873 |
| Marital status at diagnosis | ||||
| DSW | Reference | Reference | ||
| Married | 0.71(0.45~1.12) | 0.144 | 0.75(0.45~1.28) | 0.295 |
| Single | 0.54(0.34~0.85) | 0.008 | 0.56(0.33~0.96) | 0.034 |
| Unknown | 0.67(0.26~1.76) | 0.422 | 0.9(0.34~2.4) | 0.83 |
| Median household income ($) | ||||
| <50,000 | Reference | Reference | ||
| >=70,000 | 0.7(0.45~1.1) | 0.118 | 0.64(0.38~1.06) | 0.084 |
| 50,000-69,999 | 0.62(0.41~0.93) | 0.022 | 0.65(0.41~1.03) | 0.064 |
| Age (years) | ||||
| <=51 | Reference | Reference | ||
| >=74 | 5.36(3.3~8.69) | <0.001 | 4.25(2.42~7.46) | <0.001 |
| 52-73 | 1.55(1.05~2.28) | 0.026 | 1.29(0.83~2.02) | 0.261 |
| Grade | ||||
| I/II | Reference | Reference | ||
| III/IV | 0.25(0.03~1.79) | 0.166 | NA | NA |
| Unknown | 0.31(0.04~2.22) | 0.242 | NA | NA |
| Seer stage | ||||
| Distant | Reference | Reference | ||
| Localized | 0.17(0.08~0.33) | <0.001 | 0.2(0.1~0.42) | <0.001 |
| Regional | 0.42(0.29~0.62) | <0.001 | 0.52(0.34~0.78) | 0.002 |
| Unknown | 0.82(0.3~2.22) | 0.695 | 0.78(0.25~2.47) | 0.671 |
| Stage | ||||
| I | Reference | Reference | ||
| II | 2.81(1.36~5.81) | 0.005 | 2.44(1.13~5.3) | 0.024 |
| III | 3.85(2.28~6.5) | <0.001 | 3.34(1.93~5.77) | <0.001 |
| IV | 5.17(3.05~8.76) | <0.001 | 3.68(2.08~6.5) | <0.001 |
| Unknown | 3.39(1.72~6.69) | <0.001 | 3.04(1.48~6.21) | 0.002 |
| tumor size (mm) | ||||
| <=92 | Reference | Reference | ||
| >=141 | 0.48(0.31~0.75) | 0.001 | 0.48(0.3~0.79) | 0.003 |
| 93-140 | 0.66(0.4~1.07) | 0.09 | 0.68(0.4~1.14) | 0.145 |
| Unknown | 0.98(0.62~1.56) | 0.939 | 0.77(0.45~1.31) | 0.334 |
| Lymph nodes status | ||||
| negative | Reference | Reference | ||
| positive | 1.88(1.13~3.14) | 0.015 | 1.67(0.96~2.89) | 0.07 |
| Unknown | 3.01(2.02~4.49) | <0.001 | 2.47(1.61~3.8) | <0.001 |
| CA125 | ||||
| negative | Reference | Reference | ||
| positive | 1.55(0.84~2.86) | 0.16 | 1.72(0.85~3.48) | 0.128 |
| Unknown | 1.33(0.72~2.45) | 0.359 | 1.41(0.7~2.84) | 0.34 |
The values under 0.05 were represented in bold.