Table 3.
Multivariable Cox Regression for analyzing the associated factors for small cell carcinoma of the ovary.
| Subject characteristics | Overall survival (OS) | Cancer-specific survival (CSS) | ||
|---|---|---|---|---|
| HR (95%CI) | P-value | HR (95%CI) | P-value | |
| Laterality | ||||
| Bilateral | Reference | Reference | ||
| Left | 0.68(0.4~1.14) | 0.142 | 0.74(0.41~1.31) | 0.301 |
| Only one side - side unspecified | 6.34(1.58~25.46) | 0.009 | 14.35(3.41~60.38) | <0.001 |
| Paired site, but no information concerning laterality | 0.96(0.45~2.05) | 0.914 | 0.42(0.16~1.14) | 0.09 |
| Right | 0.59(0.35~0.99) | 0.048 | 0.66(0.37~1.17) | 0.154 |
| Surgery status | ||||
| No surgery | Reference | Reference | ||
| Surgery | 0.54(0.31~0.93) | 0.026 | 0.4(0.22~0.75) | 0.004 |
| Radiation therapy | ||||
| No radiation | Reference | Reference | ||
| Radiation | 0.42(0.17~1) | 0.049 | 0.29(0.11~0.76) | 0.012 |
| Chemotherapy status | ||||
| Chemotherapy | Reference | Reference | ||
| No chemotherapy/Unknown | 0.35(0.23~0.53) | <0.001 | 0.44(0.27~0.72) | 0.001 |
| Number of primary tumors | ||||
| 1st of 2 or more primaries | Reference | |||
| One primary only | 6.4(1.9~21.6) | 0.003 | ||
| Marital status at diagnosis | ||||
| DSW | Reference | Reference | ||
| Married | 1.52(0.79~2.93) | 0.208 | 1.41(0.72~2.77) | 0.312 |
| Single | 1.19(0.61~2.34) | 0.607 | 1.04(0.52~2.08) | 0.91 |
| Unknown | 1.7(0.56~5.16) | 0.352 | 1.85(0.61~5.62) | 0.278 |
| Median household income ($) | ||||
| <50,000 | Reference | |||
| >=70,000 | 0.78(0.47~1.3) | 0.34 | ||
| 50,000-69,999 | 0.64(0.41~1) | 0.052 | ||
| Age (years) | ||||
| <=51 | Reference | Reference | ||
| >=74 | 2.55(1.21~5.38) | 0.014 | 1.93(0.85~4.36) | 0.114 |
| 52-73 | 0.63(0.37~1.08) | 0.096 | 0.38(0.2~0.71) | 0.002 |
| Seer stage | ||||
| Distant | Reference | Reference | ||
| Localized | 0.38(0.14~1.05) | 0.063 | 0.36(0.12~1.05) | 0.062 |
| Regional | 0.55(0.28~1.1) | 0.089 | 0.52(0.25~1.07) | 0.077 |
| Unknown | 1.15(0.34~3.94) | 0.824 | 0.99(0.24~4.06) | 0.994 |
| Stage | ||||
| I | Reference | Reference | ||
| II | 2.49(1.01~6.13) | 0.048 | 2.67(1.05~6.8) | 0.04 |
| III | 2.22(0.92~5.35) | 0.076 | 2.09(0.85~5.19) | 0.11 |
| IV | 1.53(0.56~4.16) | 0.405 | 1.18(0.41~3.38) | 0.762 |
| Unknown | 1.01(0.4~2.53) | 0.99 | 1.11(0.42~2.91) | 0.836 |
| tumor size (mm) | ||||
| <=92 | Reference | Reference | ||
| >=141 | 0.77(0.45~1.32) | 0.345 | 0.46(0.25~0.84) | 0.012 |
| 93-140 | 0.77(0.43~1.39) | 0.387 | 0.56(0.3~1.07) | 0.079 |
| Unknown | 0.91(0.52~1.57) | 0.727 | 0.59(0.3~1.16) | 0.125 |
| Lymph nodes status | ||||
| negative | Reference | Reference | ||
| positive | 0.94(0.5~1.76) | 0.854 | 0.69(0.36~1.33) | 0.274 |
| Unknown | 1.38(0.83~2.29) | 0.215 | 1.17(0.68~2) | 0.573 |
The values under 0.05 were represented in bold.