TABLE 5.

Altered functional response of virus-specific CD8⁺-T-cell clones by a single-amino-acid mutation in an immunodominant Tax peptide^a

Function	Response with:
	Tax 11–19	Tax 11–19 (15Y→A)
[3H]thymidine incorporation	+	−
Cytotoxicity	+	+
p56lck activity	+	+
IL-2 secretion	+	−
IFN-γ secretion	+	(+)
MIP-1α secretion	+	+
MIP-1β secretion	+	(+)

^aData compiled from references 84 and 123.