Table 5.
Standard thermodynamic properties of antigen-receptor binding of SARS-CoV-2 variants. This table shows data on dissociation equilibrium constants, Kd, binding equilibrium constants, KB, and standard Gibbs energies of binding, ΔBG⁰. The data are for binding of the spike glycoprotein trimer (SGP) of SARS-CoV-2 to the human ACE2 receptor. All the data are at 25°C (298.15 K). The Kd values were taken from Wang et al. (2022).
| Variant | Kd (M) | KB (M−1) | ΔBG⁰ (kJ/mol) |
|---|---|---|---|
| BQ.1 | 6.2E-10 | 1.613E+09 | -52.55 |
| BQ.1.1 | 5.6E-10 | 1.786E+09 | -52.81 |
| XBB | 2E-09 | 5.000E+08 | -49.65 |
| XBB.1 | 2.06E-09 | 4.854E+08 | -49.58 |
| BA.2 | 9.5E-10 | 1.053E+09 | -51.50 |
| BA.4/5 | 6.1E-10 | 1.639E+09 | -52.59 |