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Dissociation constant (Kd) determined via fluorescence-based thermal shift assay.
| Compound | Dissociation constant (Kd) |
|---|---|
| Diltiazem hydrochloride (1) | ≈ 44 ± 8 μM |
| Mefenamic acid (2) | ≈ 15 ± 3 μM |
| Losartan potassium (3) | ≈ 64 ± 4 μM |
| Mexiletine hydrochloride (4) | ≈ 21 ± 5 μM |
| Flurbiprofen (7) | ≈ 66 ± 3 μM |
| Chloroquine phosphate (11) | ≈ 49 ± 9 μM |
