1. Adjusted mean differences (MD) reported in the CFHealthHub study.
|
Outcomes (measured at 12 months) |
Unit of measurement |
CFHealthHub | Usual care | Adjusted MD (95% CI) as reported in the original paper | ||
| n | Mean (SD) | n | Mean (SD) | |||
| Objectively measured effective adherence | % | 293 | 52.9 (31.4) | 295 | 34.9 (31.7) | 9.5% (95% CI 8.6 to 10.4) |
| Treatment burden: CFQ‐R treatment burden domain score | CFQ‐R score (0 to 100); higher is better |
265 | 56.6 (19.5) | 274 | 51.5 (19.7) | 3.9 (95% CI 1.2 to 6.7) |
| QoL: physical domain | CFQ‐R score (0 to 100); higher is better |
264 | 55.8 (30.2) | 274 | 52.6 (30.6) | 2.3 (95% CI ‐1.0 to 5.6) |
| QoL: emotional domain | CFQ‐R score (0 to 100); higher is better |
264 | 66.6 (22.9) | 274 | 66.5 (24.7) | 0.2 (95% CI ‐2.9 to 3.2 ) |
| QoL: social domain | CFQ‐R score (0 to 100); higher is better |
264 | 60.5 (20.0) | 274 | 59.6 (20.0) | 0.3 (95% CI ‐2.2 to 2.7) |
| QoL: eating domain | CFQ‐R score (0 to 100); higher is better |
264 | 84.0 (21.5) | 274 | 81.0 (23.2) | 1.9 (95% CI ‐1.3 to 5.2) |
| QoL: body image domain | CFQ‐R score (0 to 100); higher is better |
264 | 67.2 (27.3) | 274 | 65.1 (29.3) | 1.7 (95% CI ‐1.4 to 4.8) |
| QoL: respiratory domain | CFQ‐R score (0 to 100); higher is better |
263 | 58.0 (22.5) | 271 | 56.6 (21.9) | 0.7 (95% CI ‐2.4 to 3.8) |
| QoL: digestion domain | CFQ‐R score (0 to 100); higher is better |
263 | 80.4 (19.4) | 272 | 80.2 (21.6) | 1.1 (95% CI ‐1.7 to 3.9) |
| Adverse effects: GAD‐7 anxiety score |
GAD‐7 (0 to 21); lower is better |
262 | 4.9 (5.3) | 273 | 4.5 (4.8) | 0.3 (95% CI ‐0.4 to 1.0) |
| Adverse effects: PHQ‐8 depression score |
PHQ‐8 (0 to 24); lower is better |
262 | 6.3 (5.6) | 272 | 6.4 (5.0) | ‐0.1 (95% CI ‐0.8 to 0.7) |
| FEV1 | % predicted | 274 | 60.6 (24.2) | 282 | 56.9 (23.0) | 1.4 % predicted (95% CI ‐0.2 to 3.0) |
| Exacerbation rate (number of exacerbations per year) |
Adjusted rate | 304 | 1.63 (482 exacerbations, 294.9 person years) |
303 | 1.77 (526 exacerbations, 297.2 person years) |
0.96 (95% CI 0.83 to 1.12) |
Taken directly from the paper (CFHealthHub 2017).
CFQ‐R: Cystic Fibrosis Questionnaire ‐ Revised; CI: confidence interval; FEV1: forced expiratory volume in 1 second; GAD‐7: Generalised Anxiety Disorder score; MD: mean difference; PHQ‐8: Patient Health Questionnaire; QoL: quality of life