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. 2023 Feb 3;2023(2):CD013733. doi: 10.1002/14651858.CD013733.pub2

Comparison 2. Digital technology (web‐based online platform) versus usual care.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
2.1 Treatment adherence 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
2.1.1 At 12 months 1 588 Mean Difference (IV, Fixed, 95% CI) 18.00 [12.90, 23.10]
2.2 Quality of Life CFQ‐R score: treatment burden 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
2.2.1 12 months 1 539 Mean Difference (IV, Fixed, 95% CI) 5.10 [1.79, 8.41]
2.3 Quality of Life CFQ‐R score: other domains 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
2.3.1 CFQ‐R: physical domain score at 12 months 1 538 Mean Difference (IV, Fixed, 95% CI) 3.20 [‐1.94, 8.34]
2.3.2 CFQ‐R: emotional domain score at 12 months 1 538 Mean Difference (IV, Fixed, 95% CI) 0.10 [‐3.92, 4.12]
2.3.3 CFQ‐R: social domain score at 12 months 1 538 Mean Difference (IV, Fixed, 95% CI) 0.90 [‐2.48, 4.28]
2.3.4 CFQ‐R: eating domain score at 12 months 1 538 Mean Difference (IV, Fixed, 95% CI) 3.00 [‐0.78, 6.78]
2.3.5 CFQ‐R: body image domain score at 12 months 1 538 Mean Difference (IV, Fixed, 95% CI) 2.10 [‐2.68, 6.88]
2.3.6 CFQ‐R: respiratory domain score at 12 months 1 534 Mean Difference (IV, Fixed, 95% CI) 1.40 [‐2.37, 5.17]
2.3.7 CFQ‐R: digestion domain score at 12 months 1 535 Mean Difference (IV, Fixed, 95% CI) 0.20 [‐3.28, 3.68]
2.4 Adverse effects ‐ anxiety and depression score 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
2.4.1 GAD‐7 anxiety score at 12 months 1 535 Mean Difference (IV, Fixed, 95% CI) 0.40 [‐0.46, 1.26]
2.4.2 PHQ‐8 depression score at 12 months 1 534 Mean Difference (IV, Fixed, 95% CI) ‐0.10 [‐1.00, 0.80]
2.5 Adverse effects 1   Odds Ratio (M‐H, Fixed, 95% CI) Subtotals only
2.5.1 All adverse events at 12 months 1 608 Odds Ratio (M‐H, Fixed, 95% CI) 1.19 [0.86, 1.64]
2.5.2 Serious adverse events at 12 months 1 608 Odds Ratio (M‐H, Fixed, 95% CI) 1.36 [0.88, 2.10]
2.6 FEV1 % predicted 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
2.6.1 At 12 months 1 556 Mean Difference (IV, Fixed, 95% CI) 3.70 [‐0.23, 7.63]