| Study | Reason for exclusion |
|---|---|
| Aitken 2011 | Digital technology used for early identification of pulmonary exacerbations and not adherence monitoring. |
| Bodnar 2016 | Systematic literature review not primary research |
| Daniels 2013 | Cochrane Review not primary research |
| Elkins 2006 | Ineligible intervention: this RCT compared 2 different strengths of saline (0.9% saline or 7% hypertonic saline) with adherence measured in all participants via diary and nebuliser refill data. Investigators took a random sample of 145 participants and measured adherence in 3 ways, including via a device that logged nebuliser use. Participants were not randomised to a digital intervention or to a control. |
| ISRCTN37959826 | Not specifically adherence to inhaled medication. The study used a programme of online information describing how medications work and how they should be taken. The outcomes are measures of total prescription adherence and not specifically inhaled therapies. |
| NCT00185549 | Not specifically adherence to inhaled therapies. The study used an internet‐based programme to encourage self‐care behaviour leading to improved nutritional status. |
| NCT01183286 | Ineligible intervention. Digital technology was not used for monitoring adherence to inhaled therapy. The intervention was a smartphone app which contained medical and behavioural information, disease management tools and social networking features with the aim of increasing CF knowledge, improving adherence to the treatment regimen, improving quality of life and enhancing social support. Adherence was measured using Pharmacy Refill Data. |
| NCT02122289 | Study did not monitor adherence to inhaled therapy. It was a digital intervention to detect and identify exacerbations at an earlier stage. |
| NCT03052231 | Ineligible participant group. The study aimed to provide interactive mobile health information to support health professionals by supporting patient empowerment. The programme encompassed information, appointment reminders, medication adherence reminders and general health education. It was not specifically looking at adherence to inhaled therapies. |
| Quittner 2001 | Not an RCT |
| Sands 2013 | Ineligible intervention. No comparison of digital technology. Participants were randomised to 1 of 2 tobramycin solutions and digital technology was used to monitor adherence of all participants. |
RCT: randomised controlled trial