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SDSA models. (A) Simple SDSA model. Both 3′ ends invade the template and initiate new DNA synthesis. (B) SDSA model with bubble migration. (C) SDSA model with crossing over. Following strand annealing of the second 3′ end with the displaced strand, a double HJ intermediate can occur. (D) Repair replication fork capture model. Strand invasion initiates both leading- and lagging-strand synthesis. Because of branch migration following DNA synthesis, this is an SDSA model.
