Figure 2.

Cytokine protein levels. Fibroblast cell cultures were exposed to hemostats for 6 and 24 hours (h). Protein levels of TGF-β (A) and TNF-α (B) were analyzed from cell lysates. ORC and ONRC reduced TGF-β levels after 6 h, while protein levels normalized after 24 h of exposure (A). ONRC reduced TNF-α levels after 6 and 24 h, while ORC reduced TNF-α levels after 24 h (B). No differential regulation vs. control was observed for GELA (A and B). **p < 0.05 ORC and/or ONRC vs. control and GELA; ***p < 0.05 ONRC vs. control, GELA and ORC. Two-way ANOVA with 2-stage step-up method of Benjamini, Krieger and Yekutieli was applied (q = 0.05, n = 4–5 samples/time point)