Table 2.

Risk factors included in some of the most recently developed and widely used models and currently available tools to support risk calculation.

	BCSC [33]	BOADICEA [21]	Gail [34]	Tyrer–Cuzick/IBIS [31]	iCARE [32]	QCancer10 [36]
Genetic/familial risk factors
Family history	•	•	•	•	•	•
Rare pathogenic variants in moderate- and high-risk susceptibility genes		•		•
Polygenic risk score	•	•		•	•
Demographic factors
Country of origin (country-specific cancer incidence)		•
			•
Birth cohort/decade of birth		•
Ashkenazi Jewish ancestry		•		•
Ethnicity (other than European/Ashkenazi Jewish)	•					•
Lifestyle factors
Body mass index		•		•	•
Height		•		•	•
Alcohol use		•			•	•
Hormonal/reproductive factors
Age at menarche		•	•	•	•
Oral contraceptive use		•			•	•
Age at menopause		•			•
Menopausal hormone therapy		•		•	•	•
Number of live births		•		•	•
Age at first live birth		•	•	•	•
Other factors
Mammographic density	•	•		•
History of hyperplasia/benign disease			•	•	•	•
History of lobular carcinoma in situ				•
Previous breast biopsy	•		•	•
Manic depression or schizophrenia						•
Prior lung, blood or ovarian cancer						•
Tools to support risk calculation
Online tool	tools.bcsc-scc.org/AdvBC6yearRisk/#/	canrisk.org/	bcrisktool.cancer.gov/	ibis-risk-calculator.magview.com/		qcancer.org/10yr/female/
Software package for integration within electronic healthcare records						•

BCSC Breast Cancer Surveillance Consortium, BOADICEA Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm, iCARE Individualised Coherent Absolute Risk Estimators.