Table 1. Donepezil Increased the NREM Bout Number in Young Mice in the Active Phase.
| young |
aged |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| wake |
NREM |
wake |
NREM |
||||||
| bout number (SEM), ZT 12–14 | average bout duration, ZT 12–14 (s) (SEM) | bout number (SEM), ZT 12–14 | average bout duration, ZT 12–14 (s) (SEM) | bout number (SEM), ZT 12–14 | average bout duration, ZT 12–14 (s) (SEM) | bout number (SEM), ZT 12–14 | average bout duration, ZT 12–14 (s) (SEM) | ||
| donepezil (mg/kg) | vehicle | 97.86 (5.384) | 194.0 (12.34) | 87.93 (4.686) | 117.0 (7.916) | 124.6 (12.32) | 166.1 (21.20) | 118.2 (12.47) | 100.4 (11.81) |
| 0.1 | 106.9 (3.741) | 172.1 (9.948) | 100.6 (4.046) | 102.7 (3.714) | 119.4 (13.12) | 203.1 (48.01) | 112.4 (12.56) | 105.5 (11.06) | |
| 0.3 | 97.93 (3.679) | 190.0 (8.692) | 89.14 (3.430) | 113.8 (6.711) | 136.5 (13.07) | 149.7 (17.10) | 130.3 (12.97) | 87.93 (9.329) | |
| 1 | 104.2 (5.233) | 183.8 (13.85) | 100.6 (5.366) | 101.1 (4.077) | 108.3 (11.22) | 174.1 (21.63) | 104.3 (10.63) | 123.0 (9.635) | |
| 3 | 107.6 (4.579) | 160.2 (8.768) | 105.1 (4.371)a | 109.3 (4.910) | 122.0 (8.971) | 147.1 (15.45) | 120.1 (9.290) | 101.2 (6.153) | |
| 1-way ANOVA | F4,52 = 1.263 | F4,52 = 2.244 | F4,52 = 3.765 | F4,52 = 2.241 | F4,52 = 9.779 | F4,52 = 0.8950 | F4,52 = 0.9223 | F4,52 = 2.805 | |
| P value | 0.2963 | 0.0768 | 0.0092 | 0.0772 | 0.4277 | 0.4737 | 0.4581 | 0.0349 | |
a
p < 0.05, Dunnett’s multiple comparisons compared to the vehicle condition.