CENTRAL ILLUSTRATION PVDOMICS Protocol Elements, Enrollment, and Key Findings.

PVDOMICS is a precision medicine initiative to characterize pulmonary vascular disease using deep phenotyping. PVDOMICS tests the hypothesis that integration of clinical metrics with omic measures will enhance understanding of pulmonary vascular disease and facilitate an updated pulmonary vascular disease classification. Subjects across the spectrum of pulmonary vascular disease, comparators, and healthy control subjects were enrolled including mild and mixed etiology pulmonary vascular disease. Novel findings include enlarged right atrial volume in groups 1–4 pulmonary hypertension; unexpected, frequent presence of ground glass opacities on computed tomography and sleep alterations in group 1 pulmonary hypertension; and poorest survival in group 3 PH. PVDOMICS will facilitate new understanding of pulmonary vascular disease and refine the current pulmonary vascular disease classification.

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