Table 4.
Demographics, Anthropometrics, Clinical Laboratory Values
| Factor | Healthy Control Subjects (n = 96) | Group 1 WSPH (n = 353) Comparators (n = 58) | Group 2 WSPH (n = 136) Comparators (n = 140) | Group 3 WSPH (n = 172) Comparators (n = 119) | Group 4 WSPH (n = 57) Comparators (n = 23) | Group 5 WSPH (n = 32) Comparators (n = 7) | Overall PH or Comparator P Value | |
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| Demographics | ||||||||
| Age, y | PH | 48.4 [36.0, 58.7] {0} | 54.1 [41.4, 63.3] {0}a | 69.8 [61.2, 76.5] {0}a | 65.1 [57.1, 72.6] {0}a | 56.7 [48.5, 68.7] {0} | 58.6 [47.1, 70.3] {0} | <0.001 |
| Comparator | - | 63.5 [54.7, 72.4] {0} | 63.0 [53.8, 71.9] {0} | 62.9 [56.2, 68.8] {0} | 52.7 [39.3, 61.9] {0} | 61.6 [43.5, 66.8] {0} | 0.004 | |
| Female | PH | 67 (69.8) {0} | 259 (73.4) {0} | 78 (57.4) {0} | 88 (51.2) {0} | 35 (61.4) {0} | 11 (34.4) {0} | <0.001 |
| Comparator | - | 46 (79.3) {0} | 76 (54.3) {0} | 64 (53.8) {0} | 12 (52.2) {0} | 6 (85.7) {0} | 0.000 | |
| Hispanic ethnicity | PH | {0} | {0} | {0} | {0} | {0} | {0} | 0.058 |
| No | 81 (84.4) | 302 (85.6) | 128 (94.1) | 149 (86.6) | 50 (87.7) | 26 (81.3) | ||
| Yes | 14 (14.6) | 43 (12.2) | 5 (3.7) | 16 (9.3) | 6 (10.5) | 5 (15.6) | ||
| Unknown or not reported | 1 (1.0) | 8 (2.3) | 3 (2.2) | 7 (4.1) | 1 (1.8) | 1 (3.1) | ||
| Hispanic ethnicity | Comparator | - | {0} | {0} | {0} | {0} | {0} | 0.34 |
| No | - | 49 (84.5) | 128 (91.4) | 107 (89.9) | 19 (82.6) | 6 (85.7) | ||
| Yes | - | 6 (10.3) | 6 (4.3) | 6 (5.0) | 2 (8.7) | 1 (14.3) | ||
| Unknown or not reported | - | 3 (5.2) | 6 (4.3) | 6 (5.0) | 2 (8.7) | 0 (0.0) | ||
| Race | PH | {0} | {0} | {0} | {0} | {0} | {0} | <0.001 |
| Black or African American | 9 (9.4) | 37 (10.5) | 15 (11.0) | 22 (12.8) | 13 (22.8) | 19 (59.4) | ||
| White | 85 (88.5) | 268 (75.9) | 115 (84.6) | 138 (80.2) | 41 (71.9) | 11 (34.4) | ||
| Other | 2 (2.1) | 37 (10.5) | 5 (3.7) | 7 (4.1) | 1 (1.8) | 2 (6.3) | ||
| Unknown or not reported | 0 (0.0) | 11 (3.1) | 1 (0.74) | S (2.9) | 2 (3.5) | 0 (0.0) | ||
| Race | Comparator | - | {0} | {0} | {0} | {0} | {0} | 0.008 |
| Black or African American | - | 6 (10.3) | 8 (5.7) | 6 (5.0) | 7 (30.4) | 3 (42.9) | ||
| White | - | 49 (84.5) | 128 (91.4) | 106 (89.1) | 13 (56.5) | 4 (57.1) | ||
| Other | - | 2 (3.4) | 4 (2.9) | 4 (3.4) | 1 (4.3) | 0 (0.0) | ||
| Unknown or not reported | - | 1 (1.7) | 0 (0.0) | 3 (2.5) | 2 (8.7) | 0 (0.0) | ||
| Anthropometrics | ||||||||
| BMI, kg/m2 | PH | 27.4 [22.1, 31.5] {2} | 27.4 [23.7, 32.9] {0} | 32.7 [26.3, 37.3] {0} | 28.2 [23.6, 34.2] {0} | 31.1 [26.4, 36.1] {0} | 26.4 [23.2, 33.4] {0} | <0.001 |
| Comparator | - | 27.0 [23.8, 32.0] {0} | 31.2 [27.2, 36.6] {0} | 28.7 [24.4, 32.8] {0} | 32.5 [28.1, 36.5] {0} | 29.1 [25.2, 35.1] {0} | <0.001 | |
| Systolic blood pressure, mm Hg | PH | 122.0 [112.0, 134.0] {1} | 112.0 [103.0, 124.0] {2}a | 127.0 [112.0, 146.0] {1} | 122.5 [109.0, 136.0] {0} | 127.0 [113.0, 138.0] {0} | 115.5 [106.5, 133.5] {0} | <0.001 |
| Comparator | - | 122.0 [113.0, 132.0] {0} | 123.0 [110.0, 137.0] {1} | 121.0 [109.0, 136.0] {1} | 125.0 [119.0, 137.0] {0} | 127.0 [108.0, 154.0] {0} | 0.51 | |
| Diastolic blood pressure, mmHg | PH | 74.0 [69.0, 84.0] {1} | 69.0 [63.0, 76.0] {2} | 70.0 [64.0, 79.0] {1} | 72.0 [64.0, 81.5] {0} | 74.0 [65.0, 81.0] {0} | 71.0 [65.5, 79.0] {0} | 0.005 |
| Comparator | - | 70.0 [63.0, 78.0] {0} | 72.0 [65.0, 79.0] {1} | 71.0 [65.0, 83.0] {1} | 75.0 [71.0, 85.0] {0} | 76.0 [61.0, 78.0] {0} | 0.11 | |
| Heart rate, beats/min | PH | 69.0 [61.0, 79.0] {1} | 76.0 [66.0, 86.0] {3}a | 70.0 [61.0, 78.0] {1} | 79.5 [70.0, 91.0] {0}a | 75.0 [68.0, 83.0] {0} | 79.0 [69.5, 90.5] {0} | <0.001 |
| Comparator | - | 70.5 [64.0, 82.0] {0} | 69.0 [63.0, 80.0] {1} | 75.0 [66.0, 83.0] {1} | 69.0 [61.0, 76.0] {0} | 69.0 [66.0, 76.0] {0} | 0.052 | |
| Clinical laboratory values | ||||||||
| NT-proBNP, pg/mL | PH | 48.6 [25.9, 74.6] {7} | 256.5 [96.8, 994.9] {15}a | 1073.0 [370.6, 2,284.0] {5}a | 359.5 [118.1, 1,441.0] {6}a | 184.1 [83.1, 871.8] {1}a | 99.7 [34.7, 713.4] {1} | <0.001 |
| Comparator | - | 112.8 [64.1, 222.0] {1} | 382.9 [111.2, 920.7] {2} | 85.8 [44.7, 193.6] {3} | 72.1 [44.4, 126.4] {2} | 163.6 [73.5, 925.0] {0} | <0.001 | |
| Positive rheumatoid factor, n | PH | 3 (3.3) {6} | 32 (9.4) {13} | 15 (11.5) {5} | 18 (10.8) {6} | 4 (7.1) {1} | 2 (6.5) {1} | 0.83 |
| Comparator | - | 7 (12.1) {0} | 8 (5.7) {0} | 11 (9.5) {3} | 2 (9.5) {2} | 0 (0.0) {0} | 0.47 | |
| Positive antinuclear antibody, ANA, n | PH | 15 (17.9) {12} | 113 (39.0) {63}a | 58 (55.2) {31} | 57 (42.2) {37} | 13 (28.9) {12} | 3 (11.5) {6} | <0.001 |
| Comparator | - | 29 (63.0) {12} | 50 (42.7) {23} | 39 (40.6) {23} | 4 (20.0) {3} | 2 (33.3) {1} | 0.007 | |
Values are median [P25, P75] {n of missing}, or n (column %) {n of missing}. P values calculated as follows: Kruskal-Wallis test for continuous and ordinal variables, Pearson’s chi-square or Fisher exact test for categorical variables.
a
Significant difference at level 0.05 between comparators and PH participants within the group. No corrections for multiple testin0 were applied. 7 group 5 comparators are shown for descriptive purposes only, they were not included in the statistical comparisons. For race and ethnicity, the “other/unknown” category is shown for descriptive purposes only, they were not included in the statistical comparisons. Positive ANA is defined as titer ≥1:160 or positive ANA value obtained by immunoassay. Positive RA factor is defined as >20 lU/ml