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. Author manuscript; available in PMC: 2023 Oct 1.
Published in final edited form as: Synthesis (Stuttg). 2022 Jun 9;54(19):4210–4219. doi: 10.1055/a-1811-8075

Scheme 6.

Scheme 6.

A) Plausible transition states of enantiodetermining steps for 6a with ligand 9 as determined at the B3LYP/SDD/6–31+G(d) level of theory. B) NCI plots of plausible transition states (blue=attraction; green=weak interaction; red=steric effect)