TABLE 1.
Representative PAS domain-containing proteins from the three kingdoms of life
| Protein or open reading frame and species | Description | Accession no.a |
|---|---|---|
| Bacteria | ||
| Proteobacteria | ||
| α-Subdivision | ||
| FixL (Sinorhizobium meliloti) | Sensor kinase, oxygen-dependent regulator of nitrogen fixation | P: S39984 |
| EsxG (Sinorhizobium meliloti) | Sensor kinase controlling succinoglycan synthesis | GB: AJ225561 |
| NtrY (Azorhizobium caulinodans) | Sensor kinase controlling nitrogen level | SP: Q04850 |
| NwsA (Bradyrhizobium japonicum) | Sensor kinase controlling nodulation response | P: S39901 |
| NodV (Bradyrhizobium japonicum) | Sensor kinase controlling nodulation response | SP: P15939 |
| NtrB (Azospirillum brasilense) | Sensor kinase controlling nitrogen assimilation | P: I39493 |
| PpsR (Rhodobacter sphaeroides) | Sensor kinase, redox-dependent regulator of photosynthesis | GB: L37197 |
| DctS (Rhodobacter capsulatus) | Sensor kinase controlling dicarboxylate transport | SP: P37739 |
| PleC (Caulobacter crescentus) | Sensor kinase controlling polar organelle development | P: S27533 |
| McpA (Agrobacterium tumefaciens) | Chemotaxis transducer (?) | GB: AF010180 |
| β-Subdivision | ||
| TutC (Thauera sp. strain T1) | Sensor kinase controlling toluene degradation | GB: U57900 |
| BvgS (Bordetella bronchiseptica) | Sensor kinase controlling virulence | P: S17944 |
| γ-Subdivision | ||
| Aer (Escherichia coli) | Oxygen (redox) taxis transducer | SP: P50466 |
| ArcB (Escherichia coli) | Sensor kinase, redox-dependent regulator of aerobic metabolism | SP: P22763 |
| PhoR (Escherichia coli) | Sensor kinase controlling phosphate regulon | SP: P08400 |
| ATOS (Escherichia coli) | Sensor kinase controlling ornithine decarboxylase antizyme | SP: Q06067 |
| TodS (Pseudomonas putida) | Sensor kinase controlling toluene degradation | GB: U72354 |
| StyS (Pseudomonas sp.) | Sensor kinase controlling styrene degradation | GB: AJ000330 |
| NifL (Azotobacter vinelandii) | Sensor, redox-dependent regulator of nitrogen fixation | SP: P30663 |
| δ-subdivision | ||
| SdeK (Myxococcus xanthus) | Sensor kinase controlling fruiting-body development | GB: AF031084 |
| DcrA (Desulfovibrio vulgaris) | Oxygen (redox) taxis transducer (?) | SP: P35841 |
| Cyanobacteria | ||
| RcaE (Fremyella diplosiphon) | Sensor kinase, phytochrome/ethylene receptor | GB: U59741 |
| Sll1003 (Synechocystis sp.) | Sensor kinase (?) | GB: D90902 |
| Slr1212 (Synechocystis sp.) | Sensor, ethylene response regulator (?) | GB: D90905 |
| Low G+C Gram-positive bacteria | ||
| KinA (Bacillus subtilis) | Sensor kinase controlling sporulation | SP: P16497 |
| KinC (Bacillus subtilis) | Sensor kinase controlling sporulation | SP: P39764 |
| Aquificales | ||
| HksP2 (Aquifex aeolicus) | Sensor kinase (?) | GB: AE000683 |
| Archaea | ||
| Euryarchaeota | ||
| Bat (Halobacterium salinarum) | Sensor, oxygen-dependent bacterio-opsin activator | SP: P13260 |
| AF0277 (Archaeoglobus fulgidis) | Sensor kinase (?) | GB: AE001086 |
| AF1034 (Archaeoglobus fulgidis) | Chemotaxis transducer (?) | GB: AE001032 |
| MTH174 (Methanobacterium ther-moautotrophicum) | Sensor kinase (?) | GB: AE000805 |
| Eucarya | ||
| Dictyosteliida | ||
| DokA (Dictyostelium discoideum) | Sensor kinase controlling osmotic response | GB: X96869 |
| Fungi | ||
| Hemiascomycetes | ||
| YB89 (Saccharomyces cerevisiae) | Transcriptional regulator (?) | SP: P38140 |
| Euascomycetes | ||
| Wc-1 (Neurospora crassa) | Transcriptional regulator of the blue-light response | GB: X94300 |
| Wc-2 (Neurospora crassa) | Phototransducer, clock component | GB: Y09119 |
| PBP (Fusarium solani) | Transcriptional regulator | P: A57506 |
| Viridiplantae | ||
| Charophyta | ||
| Phy1b (Mesotaenium caldariorum) | Phytochrome phototransducer | GB: U31284 |
| Phy (Mougeotia scalaris) | Phytochrome phototransducer | GB: X95550 |
| Embryophyta | ||
| PhyBb (Arabidopsis thaliana) | Phytochrome phototransducer | SP: P14713 |
| NPH1 (Arabidopsis thaliana) | Sensor kinase controlling phototropism | GB: AF030864 |
| Metazoa | ||
| Nematoda | ||
| T01D3.2. (Caenorhabditis elegans) | Single-minded protein (SIM) homolog | GB: Z81110 |
| Insecta | ||
| PER (Drosophila melanogaster) | Transcriptional regulator of circadian rhythms | SP: P07663 |
| ARNT (Drosophila melanogaster) | Aryl hydrocarbon receptor nuclear translocator (ARNT) | GB: AF016053 |
| SIM (Drosophila melanogaster) | Global transcriptional regulator | SP: P05709 |
| EAG (Drosophila melanogaster) | Voltage-sensitive potassium channel subunit | SP: Q02280 |
| Actinopterygii | ||
| ARNT (Oncrhynchus mykiss) | Aryl hydrocarbon receptor nuclear translocator (ARNT) | GB: U73840 |
| Mammalia | ||
| CLOCK (Mus musculus) | Transcriptional regulator of circadian rhythms | GB: AF000998 |
| ARNT (Mus musculus) | Aryl hydrocarbon receptor nuclear translocator (ARNT) | GB: U61405 |
| SIM1 (Mus musculus) | Single-minded protein (SIM) homolog | GB: U40575 |
| m-EAG (Mus musculus) | Voltage-sensitive potassium channel subunit | GB: U04294 |
| HIF-1α (Mus musculus) | Hypoxia-inducible factor 1α | GB: U59496 |
| Humans | ||
| ARNT (Homo sapiens) | Aryl hydrocarbon receptor nuclear translocator | GB: U61405 |
| h-ERG (Homo sapiens) | Voltage-sensitive potassium channel subunit | GB: U04270 |
| HIF-1α (Homo sapiens) | Hypoxia-inducible factor 1α | GB: U22431 |
| HIF-2β (Homo sapiens) | Hypoxia-inducible factor 2α | GB: U51626 |
a
The accession number for each sequence is for the SWISS-PROT (SP), GenBank (GB), or PIR (P) database.
b
Analogous proteins are found in more than 20 species from this taxonomic group.