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Identification of SK-124 (compound 16) by in silico screening followed by iterative medicinal chemistry. (A) Homology model of SIK2 used for in silico docking. (B–E) Chemical structures of compounds. SIK2 kinase assay was assessed with a radioisotope kinase assay using recombinant full-length SIK2 and HDAC5 peptide substrate in a 10-point dose–response format. Respective IC50 values are indicated below each compound.
