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. 2022 Dec 5;119(50):e2211308119. doi: 10.1073/pnas.2211308119

Fig. 2.

Fig. 2.

Overexpression of CREB in early α/β neurons enhances LTM formation. (A) Overexpressing CREBB-a (with two independent lines: T7.1 or T25.4) or CREBB-c but not CREBB-b, CREBB-d, or CREBA proteins in early α/β neurons enhances 1-d memory after 3×S. Gal4-targeted transgene overexpression is induced at the restrictive temperature for tub-Gal80ts (30 °C) from 5 d before training until testing. (B) This enhancement lasts at least 4 d (Left). Memory is unaffected in these flies held at the permissive temperature for tub-Gal80ts (18 °C) after 3×S (Right) (C) Overexpressing CREBB-a (2 copies of T7.1 or T25.4 wild-type transgenes) in early α/β neurons enhances 1-d memory after only 1× (Left) and lasts at least 4 d (Right). (D) One-day memory is also unaffected in these flies held 18 °C after 1× (Left) and at 30 °C after 10×S (Right).