Table 2. Results of subgroup analysis.

PDE5: phosphodiesterase-5 inhibitors; PAP: peripheral arterial pressure; 6MWD: six-minute walking distance.

*Significant at p-value<0.05.

^Presented as risk ratio (95% CI).

Type of PDE5	Outcomes	MD (95% CI)	I-square
Sildenafil	PAP	−6.21 (−8.62, −3.20)*	100%
	Mortality^	0.68 (0.09-4.81)	54%
	Hospitalization^	0.76 (0.27-2.16)	75%
	6MWD	26.76 (16.25, 37.27)*	81%
Vardenafil	PAP	−5.40 (−6.28, −4.52)*	-
	Mortality^	0.09 (0.00-1.86)	-
	Hospitalization^	0.18 (0.02-1.87)	-
Tadalafil	PAP	−3.99 (−4.34, −3.64)*	49%
	Mortality^	0.45 (0.07-3.01)	0%
	Hospitalization^	0.21 (0.01-4.35)	-
	6MWD	23.48 (−1.42, 48.38)	0%