Table 4.
Evolution over periods of time of the variables associated with 30-day mortality, multivariable analyses
| Characteristics | Years | ||||
|---|---|---|---|---|---|
| 1996–2000 OR, (95% CI) |
2001–2005 OR, (95% CI) |
2006–2010 OR, (95% CI) |
2011–2015 OR, (95% CI) |
2016–2020 OR, (95% CI) |
|
| Male | 1.10, (0.85–1.43) | 1.13, (0.88–1.45) | 1.41, (1.12–1.79)* | 1.25, (1.00–1.57)* | 1.38, (1.10–1.74)* |
| Age | 0.987, (0.98–0.99)* | 0.999, (0.99–1.01) | 1.007, (1.00–1.01)* | 1.013, (1.01–1.02)* | 1.02, (1.01–1.03)* |
| Severe sepsis/septic shock | 0.62, (0.44–0.87)* | 0.68, (0.49–0.94)* | 0.76, (0.57–1.02) | 0.93, (0.70–1.23) | 0.70, (0.52–0.93)* |
| Neutropenia | 0.77, (0.41–1.43) | 0.80, (0.44–1.47) | 0.48, (0.26–0.88)* | 0.42, (0.23–0.75)* | 0.36, (0.20–0.65)* |
| McCabe fatal-rapidly fatal | 2.03, (1.52–2.70)* | 1.67, (1.27–2.19)* | 1.30, (1.01–1.68)* | 1.68, (1.31–2.15)* | 2.25, (1.75–2.89)* |
| Source | |||||
| Respiratory tract | 1.30, (0.86–1.98) | 1.26, (0.84–1.90) | 1.05, (0.71–1.56) | 0.85, (0.58–1.25) | 0.91, (0.62–1.34) |
| Intra-abdominal | 0.82, (0.41–1.64) | 1.64, (0.90–3.01) | 0.98, (0.54–1.78) | 1.14, (0.65–2.01) | 0.84, (0.47–1.51) |
| Spontaneous bacterial peritonitis in cirrhosis | 1.23, (0.53–2.83) | 0.63, (0.25–1.62) | 0.36, (0.14–0.93)* | 0.05, (0.01–0.26)* | 0.06, (0.02–0.23)* |
| Meningitis | 2.80, (1.07–7.30)* | 2.27, (0.86–6.01) | 1.52, (0.57–4.04) | 1.06, (0.40–2.86) | 1.08, (0.39–2.97) |
| Endocarditis | 0.80, (0.49–1.31) | 0.69, (0.43–1.13) | 0.61, (0.39–0.95)* | 0.47, (0.30–0.74)* | 0.54, (0.35–0.83)* |
| Urinary tract | 1.06, (0.72–1.55) | 1.34, (0.94–1.92) | 1.16, (0.85–1.60) | 1.50, (1.11–2.04)* | 1.67, (1.23–2.27)* |
| Biliary tract | 1.13, (0.67–1.89) | 1.43, (0.89–2.29) | 1.44, (0.93–2.23) | 1.93, (1.27–2.94)* | 1.59, (1.04–2.43)* |
| Aetiology | |||||
| S. aureus | 0.70, (0.46–1.06) | 0.92, (0.62–1.36) | 0.73, (0.50–1.05) | 0.79, (0.55–1.13) | 0.67, (0.47–0.97)* |
| Enterococcus spp. | 0.96, (0.47–1.96) | 0.72, (0.35–1.47) | 0.58, (0.30–1.14) | 0.96, (0.52–1.80) | 1.01, (0.55–1.88) |
| Candida spp. | 0.38, (0.12–1.20) | 0.87, (0.36–2.10) | 0.95, (0.42–2.15) | 1.30, (0.60–2.82) | 0.72, (0.32–1.61) |
| Polymicrobial bacteraemia | 1.60, (0.93–2.68) | 1.74, (1.06–2.84)* | 1.93, (1.21–3.07)* | 1.38, (0.87–2.17) | 1.76, (1.12–2.79)* |
| Inmunosuppressive treatment | 1.84, (1.17–2.90)* | 2.53, (1.66–3.86)* | 3.03, (2.02–4.55)* | 2.65 (1,76–3.99)* | 3.1, (2.09–4.6)* |
| Appropriate empirical antimicrobial treatment | 1.20, (0.90–1.61) | 1.03, (0.78–1.36) | 1.13, (0.87–1.47) | 1.59, (1.23–2.05)* | 1.42, (1.10–1.83)* |
Reference 1991–1995
*p < 0.05