Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Orthosteric and positive allosteric modulation. NPs (square), such as ANP and BNP, would bind to the orthosteric site of GC-A inducing a conformational change that would lead to cGMP generation. GC-A-positive allosteric modulator (PAM), such as MCUF-651, would bind to topographically distinct site(s) on the receptor to increase the affinity and/or efficacy of orthosteric ligands to which enhances cGMP signalling.
