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. 2023 Feb 2;15(1):2165390. doi: 10.1080/19420862.2023.2165390

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This work was authored as part of the Contributor’s official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law.

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Figure 2. — Evaluation of antibody variants and selection of variants with improved neutralizing breadth. (a) Screening of designed antibody variants for binding to trimers from CAP256V2LS-resistant virus strains and neutralization on a CAP256V2LS-resistant virus. Each row represent the results of binding in green color or neutralization in red color. Darker colors indicate better binding or neutralization. (b) Neutralization IC₅₀ of CAP256V2LS nanobody variants and scFv variants on small virus panels. (c) Neutralization IC₅₀ of PGDM1400 antibody variants on a 5-virus panel. (d) Neutralization IC₈₀ of selected CAP256V2LS and PGDM1400 antibody variants on a 30-virus panel. Geometric mean IC₈₀ values (µg/ml) are indicated at the bottom of each antibody column.