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. 2023 Feb 1;15(1):2172672. doi: 10.1080/19490976.2023.2172672

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© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Differentially enriched neuroactive functions and corresponding hub bacteria in three-month-old Alzheimer’s disease mice. (a) Differentially enriched gut–brain modules (GBMs) in the Alzheimer’s disease (AD) mice at three months of age. The mean proportion of the GBM (left) and 95% confidence intervals in the enriched group (right) are shown. The AD and wild-type (WT) groups are indicated by red and blue, respectively. (b) Comparison of the hub bacteria responsible for the differentially enriched GBMs between the AD and WT mice. The AD and WT mice are indicated by red and blue, respectively. * P < .05.