FIG. 10.

Comparison of prion proteins and prion domains. The prion domains of Ure2p and Sup35p are rich in Asn and Gln residues, and these residues are important in prion generation and propagation. PrP and the het-s protein are not Asn or Gln rich. The prion domain of the het-s protein has not been determined. For Ure2p, Sup35p, and PrP, mutations outside the prion domain may have dramatic effects on prion generation or propagation (see the text). Modified from reference 105 with permission of the publisher.