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LOWESS curves of MDS-UPDRS Part 3 total score (A and D), sum scores of non-tremor items (B and E), and tremor items (C and F) in the pre-levodopa therapy dataset (A-C, time zero is the baseline visit) and the levodopa therapy dataset (D-E, time zero is the visit when patients required levodopa medication) as percentages of the possible total scores. Abbreviations: LOWESS, locally weighted scatterplot smoothing.
