Table 1. Autophagy enhancers in Alzheimer's disease animal models.

Compound	Mechanism	Target	Model	Reference
AMPK: adenosine 5'-monophosphate (AMP)-activated protein kinase; cAMP: cyclic Adenosine monophosphate; FKBP12: FK506-binding protein 12; IMP: inosine monphosphate; mTOR: mammalian target of rapamycin; PKC: protein kinase C; PP2A: protein phosphatase 2A; PPARα: peroxisome proliferators-activated receptor α; SLC2A: solute carrier 2A; SIRT1: silent mating type information regulation 2 homolog- 1; TFEB: transcription factor EB.
Metformin	AMPK activation	AMPK	SAMP8 mice APP/PS1 mice Tg6799 mice	[114] [120] [142]
Trehalose	AMPK activation	SLC2A	APP/PS1 mice	[143]
Nilotinib	AMPK activation	c-ABL inhibitor	Tg-APP mice	[144]
Resveratrol	AMPK activation	SIRT1	APP/PS1 mice	[121]
Berberine	AMPK activation	unknown	3×Tg mice	[125,145]
Rapamycin	mTORC1 inhibition	FKBP12	PDAPP mice 3×Tg-AD mice	[127,146] [128,147]
Everolimus	mTORC1 inhibition	FKBP12	3×Tg mice	[129]
Temsirolimus	mTORC1 inhibition	mTOR	APP/PS1 mice Tg30 mice	[130] [148]
Latrepirdine	mTORC1 inhibition	unknown	TgCRND8 mice	[141]
Carbamazepine	mTORC1 inhibition	Na+ channel inhibitor	APP/PS1 mice	[149]
Rifampicin	mTORC1 inhibition	PP2A	Tg2576 mice	[150]
Curcumin analogue C1	TFEB activation	TFEB	5×FAD mice 3×Tg mice	[117]
HEP14	TFEB activation	PKC	APP/PS1 mice	[135]
Aspirin	TFEB activation	PPARα	5×FAD mice	[151]
Gemfibrozil and Wy14643	TFEB activation	PPARα	APP-PSEN1ΔE9 mice	[115]
Cinnamic acid	TFEB activation	PPARα	5×FAD mice	[152]
Gypenoside XVII	TFEB activation	unknown	APP/PS1 mice	[153]
Lithium	cAMP/IP3	IMP	APP/PS1 mice	[154]