TABLE 3.

Combined sample hazard ratios.

	Main model a	Fully adjusted model b	Competing risk model c
Combined sample	n = 24 478	n = 20 878	n = 20 645
Abstainer	Ref	Ref	Ref
≤ 1.3 g/day	0.78 (0.68, 0.89)	0.82 (0.71, 0.96)	0.73 (0.54, 0.97)
1.3–24.9 g/day	0.78 (0.70, 0.87)	0.85 (0.76, 0.96)	0.78 (0.64, 0.95)
25–44.9 g/day	0.62 (0.51, 0.75)	0.74 (0.60, 0.90)	0.65 (0.45, 0.93)
≥ 45 g/day	0.81 (0.61, 1.08)	0.78 (0.57, 1.05)	0.79 (0.58, 1.06)
Male sample	n = 10 218	n = 8873	n = 8452
Abstainer	Ref	Ref	Ref
≤ 1.3 g/day	0.69 (0.53, 0.91)	0.71 (0.53, 0.95)	0.62 (0.46, 0.82)
1.3–24.9 g/day	0.74 (0.62, 0.88)	0.84 (0.69, 1.02)	0.70 (0.55, 0.89)
25–44.9 g/day	0.59 (0.46, 0.77)	0.70 (0.54, 0.92)	0.61 (0.44, 0.84)
≥ 45 g/day	0.82 (0.60, 1.13)	0.80 (0.57, 1.13)	0.78 (0.58, 1.04)
Female sample	n = 14 260	n = 12 005	n = 12 193
Abstainer	Ref	Ref	Ref
≤ 1.3 g/day	0.80 (0.68, 0.94)	0.88 (0.73, 1.05)	0.76 (0.53, 1.09)
1.3–24.9 g/day	0.82 (0.71, 0.94)	0.88 (0.76, 1.02)	0.82 (0.67, 1.01)
25–44.9 g/day	0.63 (0.46, 0.88)	0.76 (0.55, 1.06)	0.66 (0.40, 1.10)
≥ 45 g/day	0.37 (0.12, 1.11)	0.36 (0.12, 1.10)	0.40 (0.12, 1.35)

Note: Bold = statistically significant at p < .05.

^a Model included all 15 cohorts and adjusted for age, sex, smoking status and random effect of study;

^b Model included 11 cohorts and adjusted for age, sex, smoking status, education, body mass index (BMI), depression, stroke, diabetes, myocardial infarction, hypertension, high cholesterol and random effect for study;

^c Model included 13 cohorts, adjusted for age, sex, smoking status and study as a cluster variable and accounted for competing risk of death.