Table 3.

Assessment of multiplicative effect measure modification by child sex for the relationship between gestational OPEs and preschool ADHD in a nested case-control study of preschool ADHD in MoBa, 2004–2007.

Exposure	Combineda,b,c	Boysd,e	Girlsd,f	P-valueg
	Odds Ratio (95% CI)	Odds Ratio (95% CI)	Odds	Odds Ratio (95% CI)
Log10 exposure
DPhP	1.07 (0.77, 1.48)	0.95 (0.61, 1.49)	1.23 (0.76, 2.00)	0.45
DnBP	1.30 (0.86, 1.97)	1.47 (0.84, 2.57)	1.12 (0.60, 2.11)	0.54
Exposure ≥ LODg
BBOEP	0.94 (0.69, 1.28)	1.31 (0.86, 2.00)	0.58 (0.37, 0.93)	0.01
BDCIPP	1.19 (0.83, 1.71)	1.25 (0.74, 2.11)	1.07 (0.63, 1.80)	0.67

^aRefers to full model without the incorporation of interaction terms.

^bCombined model contains 260 Preschool ADHD cases and 549 birth-year-stratified controls.

^cAll models are derived from an imputed logistic regression model adjusted for total fish consumption, maternal education, financial difficulty, maternal age, and sex.

^dStratum-specific estimates are derived from models that additionally include interaction terms for each included variable using an augmented product term approach to assess effect measure modification by sex.

^eModel for boys contains 145 Preschool ADHD cases and 275 birth-year-stratified controls.

^fModel for girls contains 115 Preschool ADHD cases and 274 birth-year-stratified controls.

^gP-value is derived from organophosphate ester*sex interaction.

^gLimit of detection.