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. Author manuscript; available in PMC: 2023 Aug 1.
Published in final edited form as: Clin Cancer Res. 2023 Feb 1;29(3):647–658. doi: 10.1158/1078-0432.CCR-22-2355

Figure 4. Differences in the normalized expansion rate of expanded top 20 TCR clonotypes between responder and non-responder TILs.

Figure 4.

(A) Little association between the sum of frequency of singleton clonotypes and the number of total productive TCR sequences (n=56) (R2=0.035). (B) No significant differences in the sum of frequency of singleton clonotypes between responders (n=5) and non-responders (n=9) for post-PBMC (p=0.44), post-TIL (p=0.52), pre-PBMC (p=0.80), and pre-TIL (p=0.90). (C-D) Significant differences in the normalized expansion rate of expanded top 20 TCR clonotypes between responders (n=5) and non-responders (n=9) for PBMC (p=0.0263) or TIL (p=2.4e-06). Statistical difference was calculated by Wilcoxon rank sum test.