Table 1.
PXID | CDR3 region amino_acid | pre_TIL_Freq | pre_TIL_Rank | post_TIL_Freq | post_TIL_Rank | Ratio_TIL | pre_PBMC_Freq | pre_PBMC_Rank | post_PBMC_Freq | post_PBMC_Rank | Ratio_PBMC |
---|---|---|---|---|---|---|---|---|---|---|---|
| |||||||||||
6 | CASSPPSRDYVSYEQYF | 1.908% | 3 | 2.263% | 1 | 1.186 | 0.31% | 8 | 0.409% | 8 | 1.321 |
15 | CASSHNVYTGELFF | 0.03% | 537 | 0.728% | 5 | 24.571 | 0.807% | 5 | 0.994% | 5 | 1.233 |
16 | CASTRTGYPAGPHNEQFF | 1.033% | 4 | 2.401% | 3 | 2.324 | 2.432% | 2 | 3.68% | 2 | 1.513 |
16 | CASSLSGGGEQYF | 0.302% | 12 | 0.913% | 8 | 3.027 | 0.194% | 16 | 0.362% | 10 | 1.871 |
22 | CASSEAETGGYEQYF | 0.111% | 125 | 1.395% | 6 | 12.628 | 0.618% | 4 | 0.952% | 2 | 1.54 |
24 | CASSSLRGPEDYGYTF | 0.802% | 1 | 3.142% | 1 | 3.919 | 0.679% | 2 | 1.222% | 3 | 1.799 |
24 | CASSSHYPTDTQYF | 0.345% | 11 | 1.29% | 7 | 3.736 | 0.287% | 6 | 0.52% | 5 | 1.814 |
24 | CAISDPRDSYEQYF | 0.274% | 13 | 0.825% | 11 | 3.007 | 0.192% | 11 | 0.224% | 18 | 1.168 |
24 | CASSDRGDPSEPQHF | 0.55% | 7 | 0.799% | 12 | 1.452 | 2.832% | 1 | 3.549% | 1 | 1.253 |
24 | CASSYSTSGQETQYF | 0.154% | 20 | 0.541% | 17 | 3.507 | 0.184% | 12 | 0.505% | 6 | 2.736 |
27 | CASSFHAGAGNTIYF | 0.668% | 5 | 1.306% | 6 | 1.955 | 0.629% | 5 | 0.967% | 6 | 1.537 |
Patient ID indicates the patient who harbors a shared expanded top TCR clonotype.
Patient 6 and 15 are non-responders and patient 16, 22, 24, and 27 are responders (in red fonts).