Table 4.

Neurotransmitter/Neuropeptide/Biochemical assay results summary

SYSTEM PATHWAY	UPREGULATION (# OF STUDIES)	DOWNREGULATION (# OF STUDIES)	NO SIGNIFICANT EFFECTS (# OF STUDIES)	UPREGULATION AND DOWNREGULATION (# OF STUDIES)
DOPAMINERGIC	1(Ponzio et al., 1977)	6 (Chaudhuri et al., 1992; Dey et al., 1991; Jori & Dolfini, 1976; Marchi & Cugurra, 1974; Shetty & Gaitonde, 1980b; Simone et al., 2015)		1 (Algeri et al., 1976)
CHOLINERGIC			2 (Daabees et al., 1981; Ladinsky et al., 1976)	1 (Bandyopadhyay & Ghosh, 1988)
LIPID PATHWAYS		1 (Islam et al., 1980)
BETA-ENDORPHIN		2 (Tejwani et al., 1985; Tejwani et al., 1983)
BDNF		1 (Simone et al., 2015)
GABA	3 (Porcu et al., 2012; Rao et al., 1984; Shetty & Gaitonde, 1980a)		1(Sassoè-Pognetto et al., 2007)	1 (Daabees et al., 1981)
SEROTONIN	1 (Daabees et al., 1981)