Table 2 :
Various GEMMs used for IPMN Study
| GEMM Phenotype | Lesions/Tumor | Time for Lesion Development | IPMN Subtype | Metastasis | References |
|---|---|---|---|---|---|
| Ptf1a-Cre; LSL-KrasG12D; and Smad4f/f | IPMN and PDAC | 2–3 Months | Gastric | YES | Bardeesy et al., 2006 |
| P48-Cre; LSL-KrasG12D; and Ela-Tgfa | IPMN, PanIN and PDAC | 2–3 Months | Pancreatobiliary | YES | Siveke et al., 2007 |
| Pdx1-Cre; LSL-KrasG12D; and Tif1γf/f | N/A | 7 Weeks | NA | NA | Vincent et al., 2009 Vincent et al., 2012 |
| LSL-KrasG12D; Pdx1-Cre+/− and TP53INP−/− | ADM, IPMN, PanIN | 2 months | NA | NA | Saati et. al., 2013 |
| Ptf1a-Cre; LSL-KrasG12D; and Brg1f/f | IPMN, PDAC | 9 Weeks | Pancreatobiliary | NA | Von Figura et al., 2014 |
| Pdx1-Cre; LSL-KrasG12D; and Acvr1bf/f | ADM, IPMN, PanIN, PDAC | 3 Months | NA | YES | Qiu et al., 2016 |
| Pdx1-Cre; LSL-KrasG12D; and Tff2−/− | IPMN, PDAC | 6 Weeks | Gastric | YES | Yamaguchi et al., 2016 |
| Ptf1a-cre; LSL-KrasG12D; and CAG-LSL-GnasR201H; | IPMN | 5 Weeks | Pancreatobiliary and Gastric | N/A | Taki et al., 2016 |
| K5 COX-2. p48-Cre/KrasG12D | IPMN, PanIN | 1 Month | Gastric | NA | Chiblak et all., 2016 |
| P48-Cre;LSL-KrasG12D Rosa26R-LSL-rtTA-Tet-OGnasR201C | IPMN (+Dox), PanIN (−Dox) | 18 weeks | Pancreatobiliary | YES | Ideno et al., 2018 |
| Sox9-CreERT2; LSL-KrasG12D; and Ptenf/+ Sox9-CreER; LSL-KrasG12D; and Lkb1f/f | IPMN | 6–12 Months 4–8 months |
Pancreatobiliary and Oncocytic Pancreatobiliary |
NA | Kopp et al., 2018 |
| Foxa3-Cre; HER2N | IPMN, PanIN, | 8 Weeks | Pancreatobiliary and Oncocytic | Shibata et al., 2018 | |
| Ptf1a-Cre; KrasG12D; and Arid1af/f | IPMN, PDAC | 2.3 Months | Pancreatobiliary, Gastric and Oncocytic | YES | Wenjia Wang et al., 2019 Kimura et al., 2018 |
| Sox9-CreER; LSL-KrasG12D; and Lkb1f/f | IPMN, PanIN, | 2 Months | Gastric | NA | Collet et al.,2019 |
| Ptf1aCre/+; Nr5a2lox/+; Kras(G12V)+/KI | IPMN,, PanIN, PDAC | 5 Months | Pancreatobiliary | NA | Cobo et al., 2020 |
| KrasLSL-G12D/+; Jag1flox/flox; Pdx1-Cre | ADM, PanIN, SCN, IPMN | 3 Weeks | NA | NA | Chung et al., 2021 |