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. Author manuscript; available in PMC: 2024 Feb 15.
Published in final edited form as: J Immunol. 2023 Feb 15;210(4):377–388. doi: 10.4049/jimmunol.2200325

Figure 6. 13C2 T cell activation does not require glycolysis.

Figure 6.

AM14 B cells and 13C2 T cells were co-transferred into DO11.10 mice immunized with PL2-3 and treated or not with 2DG for 7 d. A. Frequency of 13C2 T cells among total CD4+ T cells. B. Proliferation of 13C2 T cells. C. IL-2 and IFNγ production by 13C2 T cells. D. BCL-2 expression by 13C2 cells. E. Frequency of Tfh cells among 13C2 T cells gated as PD-1+Bcl-6+ (left) or PD-1+PSGL-1low (right) cells. Proliferation (F) and BCL-2 expression (G) in Tfh 13C2 T cells. H. IL-2 production by Tfh 13C2 T cells. I. Extra-follicular (Tef) cell frequency among 13C2 T cells. J. IL-2 production by Tef 13C2 T cells. K. Frequency of endogenous DO11.10 T cells. K. Tfh frequency among DO11.10 cells. IL-2 (L) and IFNγ (M) production by DO11.10 Tfh cells. Data were pooled from 3 experiments and values were normalized to the mean PL2-3 values as 1 in A. Each point represents a mouse and graphs show means and SEM. Comparisons between groups were performed with t tests. *P < 0.05.